Neuro - uworld Flashcards
Which nerve is involved in ocular sensation?
Trigeminal
Pt felt warm and nauseous prior to a syncopal episode
Neurocardiogenic (or vasovagal) syncope
Occurs due to excessive vagal tone
Preceded by n/v, bradycardia, or pallor
Precipitated by pain or stress
How do you correct over coagulation in a warfarin pt
Vit K and prothrombin complex concentrate (has Vit K dependent clotting factors)
Initial Tx of Guillain-Barre?
IVIG or plasmaphoresis
Wacky, wobly, wet
normal pressure hydrocephaly
Enlarged ventricles on MRI but normal opening pressure on LP
Dystonia of the SCM
Torticollis
Pt develops decreased hearing acuity and vestibular syx weeks after starting abx
Aminoglycoside (gentamicin) toxicity - hearing loss and vestibular syx
oscillopsia - sensation of objects moving in the visual field
Pt has consistent dull HA, decreased libido, and hemianopsia
Craniopharyngioma
Benign suprasellar tumor with visual defect, HA, and syx of pituitary changes
Arise from the remnant of Rathke’s pouch
Bitemporal heminopsia
Optic chiasm
Young obese female with constant dull HA and papilledema
Pseudotumor cerebri
Brain tumor w/ NL imaging and elevated CSF pressure
Tx - weight reduction and acetazolamide
If untreated - blindness
Causes of chemo induced peripheral neuropathy
Vincristine (Vinca alkaloid)
Cisplatin (platinum)
Paclitaxel (taxanes)
symmetrical parathesia in stocking and glove pattern
Pronator drift tests?
UMN or Pyramidal tract dz dz of the UE
Affected eye is unable to adduct and the contralateral eye abducts w/ nystagmus
Internuclear ophtalmoplegia
Convergence is preserved
Damage in the MLF
Worsening frontal HA’s, blurred vision when leading forward
Intracranial HTN (ICH Can have HA, n/v/ AMS,
ALS involves damage to?
the UMN (spasticity, hyperreflexia) and LMN (fasiculations)
Following a minor skin break in the face pt has severe HA, periorbital edema, EOM deficits
Cavernous sinus thrombosis
Edema because the venous system in the cavernous sisnus does not have valves
What finding confirms CNS lymphoma in a HIV +?
EBV DNA in the CSF
CT reveal global cerebral atrophy that is worse in the temporal and parietal lobes
Alzheimers
Parkinson’s is caused by an accumulation of
alpha synuclein w/in the substantia nigran
3 classic signs of PD?
resting tremor
rigidity
Bradykinesia
Best way to dx - at least two of these on PE
Pt has sparse and non fluent speech, impaired repitition, but can follow commands
Broca aphasia
can have right hemiparesis
Affects dominant temporal lobe (ie, R handed man, L hemisphere is dominant)
Lots of words w/o meaning, not able to follow commands, poor repeating
Wernicke aphasia
Fluent but with phonemic errors (sunny vs. funny), able to follow commands, no repeating
Conductive aphasia
Can see this in severe forms of Broca’s aphasia that extends to the arcuate fasciculus
loss pain and temp on ipsi face, contra body
Vertigo, nystagmus
ipsi hornor’s syndrome
Lateral medullary infarct (Wallenberg syndrome)
Occlusion of the PICA or intracerebral vertebral a.
Motor function is spared
Acute, unilateral, severe retro-orbital pain that wakes a pt up
Cluster HA
tx - oxygen
Ppx - verapamil, lithium
Pt with new onset CVA syx has a negative CT, now what?
Give TPA
Negative CT means non hemorrhagic so give TPA for best neurologic outcomes
Contra’s - hx of intracerebral bleed, BP>185/110, Platelets <100,000
INR>1.7
Pt is treated for CVA w/ sudden loss of contra senses, weeks later now has burning pain and develops allodynia (excessive pain in response to light touch) on the affected side
Thalamic pain syndrome
Pt likely had a Lacunar stroke of the posterolateral thalamus (pure sensory lacunar stroke)
Occlusion of deep branches of the PCA
Elderly w/ onset of confusion and lethargy x hours and hyperdense mass in parietal lobe
Parietal lobe hemorrhage
Most likely cause is - cerebral AMYLOID angiopathy. Most common cause of spontaneous lobar hemorrhage in an adult >60
Pt has months hx of right hand clumsiness and decreased sensation over 4th and 5th fingers
Ulnar n. syndrome
Clumsiness = weak grip
ulnar n. entrapment in the medial epicondylar groove (elbow)
Entrapment is typically caused by leaning on the elbows during work (for long periods, ie, at a desk or table)
Apparently extremely high yield for USMLE
Most common dementia in the US?
Alzheimer’s
Early memory and visospatial impairments
Can have gait impairement in advanced dz
Blindness in one eye
optic n. damage (pre chiasm) #1
Loss of left visiual field in each eye
Left homonymous hemianopia
Optic tract damage (post chiasm) OR
loss of optic radiations (temporal AND parietal)
#3 or #6
loss of bottom left corner of visiual field in each eye
Left inferior homonymous quadrantonopia
Defect in parietal optic radiations (usually #4)
Loss up top left corner of visual field
Left superior homonymous quadrantonopia
Defect in optic radiations to the temporal lobe or Meyers loop #5
Loss of left half of visual field with sparing of the center of vision
Left homonymous hemianopia w/ macular sparing
Defect in occipital cortex
Usually #7 or most posterior option
Papilledema refers to swelling of the
Optic disc
Caused by increased ICP
Ipsilateral optic disc atrophy due to compression by a space occupying lesion in the frontal lobe
papilledema in contra optic disc due to increased ICP
Foster-Kennedy syndrome
Morning HA, transient visual oscuration
Increased ICP
Caused by space occupying lesion (tumor, AVM, anuerysm, pseudotomor cerebri (IIH))
Large blind spot with intact visual acuity
Drusen (pseudopapilledema)
Caused by small hyaline concretions
Fundoscopic exam - glistening hyaline bodies
Painful visual loss that is worth with hot baths or exercise, retro-orbital pain
Optic neuritis
Suggestive of demyelination
tx - IV methylprednisone
Sudden painless visual loss in pt >50 w/ HTN or DM
Ischemia (AION) Vascular cause (occlusion, TIA) or temporal arteritis
Misalignment of the eyes
strabismus
What does the doll’s eyes test assess?
Useful in unconscious pt to evaluate integrity of the vestibular and oculomotor apparatus
Tests vestibulo-ocular movement, CN III, IV, and VIII
If intact, the reflex will rotate the eyes in the direction opposite of the head movement
Suggests nuclear dysfunction
horizontal gaze center
Paramediane Pontine reticular formation (PPRF)
Defects in MLF produce?
INO
Defect in PPRF and ipsilateral MLF
one-and-a-half syndrome
Gaze palsy to the ipsilateral side and INO in contralateral gaze
Vertical gaze center
riMLF
What is saccades?
Rapid conjugate movement of the eyes to look at objects
Defect - oculomotor apraxia
How do you tell if nystagmus is central or peripheral?
Peripheral - unilateral
Central - bilateral
Initial Tx for symptomatic myasthinia gravis?
Pyridostigmine
Achesterase inhibitor
If resistant - add an immunosuppresive like a steroid
Pt present to ER w/ new onset seizure. Now what?
labs - electrolytes
Utox
CT w/o contrast
Pt has stroke syx quickly followed by n/v
Suggestive in intracrainial hemorrhage. n/v because of increased intracranial pressure
Age-related hearing loss
Presbycusis
Progressive, b/l, symmetric
Sensorineural loss
What deficits are found in DM?
alterations of sensation and proprioception
How do you work up idiopathic UMN findings?
MRI of the spine
Most likely cause of hemorrhagic stroke in a hypertensive pt?
hypertensive vasculopathy
Fever, general muscle rigidity, autonomic instability, AMS
Neuroleptic malignant syndrome
Life threatining idiosyncratic drug rxn to DA antagonists
Look for a recent schizo or psychosis episode that would lead to taking an antipsychotic (usually in last 2 weeks), especially 1st gen antipsychotic (haloperidol)
Type B rxn - INdependent of drug dose
Tx - remove aggravating agent and provide supportive care +/- Dantrolene as needed
What are the two ways that MS will present?
- optic neuritis - mononuclear blindness, painful eye movement
- Transverse myelitis - motor and sensory loss below the level of the lesion, incontinence
Tx for depression w/ pseudodementia
SSRI
Psedodementia is a reversible cognitive impairment
When do you order an MRI for a pt with a hx of HA’s?
When the HA differs in character from the prior
Present when awakening in the morning
Causing frequent nausea, vomiting, or blurry vision
New seizure, AMS, new HA at >40, trauma
Pathophysiology of normal pressure hydrocephaly
Decreased CSF absorption -> transient increase in ICP causing ventricular enlargement w/o chronically increased pressure
Stroke presenting with unilateral motor impairment
Posterior limb of internal capsule (lacunar infarct)
Stroke involving contra motor (face arm leg)
Eye deviates toward the lesion
Homonymous hemianopia
MCA occlusion
Aphasia when affecting dominant hemisphere
Hemineglect when affecting nondominant
Can affect upper and lower extremities but usually upper is worse
Stroke involving sensory and motor of lower extremity
Abulia (lack of will, initiative)
Dyspraxia, emotional distubrance, urine incontinence
ACA occlusion
Can involve upper and lower extremities but usually the lower is worse
Stroke contra hemiplegia and ipsi CN involvement
ataxia possible
Vertebrobasilar system lesion
Supplies the brain stem, so think more basal fxn deficits
Stroke presenting with homonymous hemianopia
Visual hallucinations
Sensory syx
CN III palsy
PCA occlusion
Pathophys of lacunar strokes
Microatheroma formation and lipohyalinosis of the small penetrating arteries
RF’s - HTN, HLD, DM, and smoking
Pure motor hemiparesis = internal capsule
Often CT negative
Parkinson’s is a progressive loss of dopaminergic neurons in the
Basal Ganglia
Interrupts the neurologic connections between the thalamus and motor cortex
MG is caused by autoAb’s against ACh receptors at the
Motor end plate