Neuro/Psych Pharm Flashcards
Latanoprost (mechanism, use, toxicity)
PGF2 analog that increases the outflow of aqueous humor; can cause darkening of the iris Pharmacology Neurology
Morphine, fentanyl, cofeine, heroin, methadone, meperidine, dextromethorphan, diphenoxylate (mechanism, use, toxicity)
Mu opioid agonists that open K channels and close Ca channels, inhibting synaptic transmission; addiction, respiratory depression, constipation, miosis Pharmacology Neurology
Butorphanol (mechanism, use, toxicity)
Mu opioid partial agonist; used to treat severe pain; causes withdrawal if being treated with full agonist Pharmacology Neurology
Tramadol (mechanism, use, toxicity)
Weak opioid agonist that inhibits serotonin and NE reuptake; increases risk for seizures Pharmacology Neurology
First-line therapy for simple partial seizures
Carbamazepine Pharmacology Neurology
First-line therapy for complex partial seizures
Carbamazepine Pharmacology Neurology
First-line therapies for tonic-clonic seizures (3)
Carbamazepine, phenytoin, valproate Pharmacology Neurology
First-line therapy for absence seizures
Ethosuximide Pharmacology Neurology
Phenytoin (mechanism, use, toxicity)
Increases Na channel inactivation and inhibits glutamate release; used for simple, complex, and tonic-clonic seizures and status epilecticus prophylaxis; nystagmus, gingival hyperplasia, hirsutism, megaloblastic anemia, teratogenic, drug-induced lupus, P450 inducer Pharmacology Neurology
Carbamazepine (mechanism, use, toxicity)
Increases Na channel inactivation; first-line for simple, complex, and tonic-clonic seizures and trigeminal neuralgia; agranulocytosis, aplastic anemia, P450 inducer, SIADH, liver toxicity Pharmacology Neurology
Lamotrigine (mechanism, use, toxicity)
Blocks Na channels; used for simple, complex, and tonic-clonic seizures; Steven-Johnson syndrome Pharmacology Neurology
Gabapentin (mechanism, use, toxicity)
Inhibits Ca channels; used for simple, complex, and tonic-clonic seizures, migraine prophylaxis, peripheral neuropathy, bipolar disorder; ataxia Pharmacology Neurology
Topiramate (mechanism, use, toxicity)
Blocks Na channels and increases GABA secretion; used for simple, complex, and tonic-clonic seizures and migraine prevention; mental dulling, kidney stones, weight loss Pharmacology Neurology
Phenobarbital (mechanism, use, toxicity)
Increases GABA channel action; first-line for simple, complex, and tonic-clonic seizures in children; P450 inducer Pharmacology Neurology
Valproate (mechanism, use, toxicity)
Increases Na channel inactivation and increases GABA levels; first-line for tonic-clonic seizures, used for simplex, complex, tonic-clonic, and myoclonic seizures; hepatotoxicity, neural tube defects, weight gain, tremor Pharmacology Neurology
Ethosuximide (mechanism, use, toxicity)
Blocks thalamic Ca channels; first-line for absence seizures; GI distress, Steven-Johnson syndrome Pharmacology Neurology
Benzodiazepines (mechanism, use, toxicity)
Increases frequency of GABA channel opening; first-line for status epilepticus (diazepam, lorazepam), used for eclampsia seizures (diazepam, lorazepam), anxiety, alcohol withdrawl, sleep walking, night terrors; sedation Pharmacology Neurology
Tiagabine (mechanism, use, toxicity)
Inhibits GABA reuptake; used for simple and complex seizures Pharmacology Neurology