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Rapid Review STEP 1 > Classic Labs-Findings > Flashcards

Classic Labs-Findings Flashcards

2
Q

Classic Labs-Findings

Anticentromere antibodies

A

Scleroderma (CREST)

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3
Q

Classic Labs-Findings

Antidesmoglein (epithelial) antibodies

A

Pemphigus vulgaris (blistering)

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4
Q

Anti-glomerular basement membrane antibodies

A

Goodpasture’s syndrome (glomerulonephritis and hemoptysis)

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5
Q

Antihistone antibodies

A

Drug-induced SLE (hydralazine, isoniazid, phenytoin, procainamide)

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6
Q

Anti-IgG antibodies

A

Rheumatoid arthritis (systemic inflammation, joint pannus, boutonniere deformity)

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7
Q

Antimitochondrial antibodies (AMAs)

A

Primary biliary cirrhosis (female, cholestasis, portal hypertension)

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8
Q

Antineutrophil cytoplasmic antibodies (ANCAs)

A

Vasculitis (c-ANCA: Wegener’s; p-ANCA: microscopic polyangiitis, Churg-Strauss syndrome)

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9
Q

Antinuclear antibodies (ANAs: anti-Smith and anti-dsDNA)

A

SLE (type 3 hypersensitivity)

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10
Q

Antiplatelet antibodies

A

Idiopathic thrombocytopenic purpura (ITP)

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11
Q

Anti-topoisomerase antibodies

A

Diffuse systemic scleroderma

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12
Q

Anti-transglutaminase/anti-gliadin/anti-endomysial antibodies

A

Celiac disease (diarrhea, distention, weight loss)

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13
Q

“Apple core” lesion on abdominal x-ray

A

Colorectal cancer (usually left-sided)

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14
Q

Azurophilic granular needles in leukemic blasts

A

Auer rods (acute myelogenous leukemia, especially the promyelocytic [M3] type)

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15
Q

Bacitracin response

A

Sensitive: Streptococcus pyogenes (group A); resistant: Streptococcus agalactiae (group B)

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16
Q

“Bamboo spine” on x-ray

A

Ankylosing spondylitis (chronic inflammatory arthritis: HLA-B27)

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17
Q

Basophilic nuclear remnants in RBCs

A

Howell-Jolly bodies (due to splenectomy or nonfunctional spleen)

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18
Q

Basophilic stippling of RBCs

A

Lead poisoning or sideroblastic anemia

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19
Q

Bloody tap on LP

A

Subarachnoid hemorrhage

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20
Q

“Boot-shaped” heart on x-ray

A

Tetralogy of Fallot, RVH

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21
Q

Branching gram-postive rods with sulfur granules

A

Actinomyces israelii

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22
Q

Bronchogenic apical lung tumor

A

Pancoast tumor (can compress sympathetic ganglion and cause Horner’s syndrome)

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23
Q

“Brown” tumor of bone

A

Hemorrhage (hemosiderin) causes brown color of osteolytic cysts. Due to: 1. Hyperparathyroidism 2. Osteitis fibrosa cystica

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24
Q

Cardiomegaly with apical atrophy

A

Chaga’s disease (Trypanosoma cruzi)

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25
Q

Cellular crescents in Bowman’s capsule

A

Rapidly progressive crescentic glomerulonephritis

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26
Q

“Chocolate cyst” of the ovary

A

Endometriosis (frequently involves both ovaries)

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27
Q

Circular grouping of dark tumor cells surrounding pale neurofibrils

A

Homer Wright rosettes (Neuroblastoma, medulloblastoma, retinoblastoma)

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28
Q

Colonies of mucoid Pseudonomas in lungs

A

Cystic fibrosis (AR mutation to CFTR resulting in fat-soluble vitamin deficiency and mucous plugs)

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29
Q

Decreased alpha-fetoprotein in amniotic fluid/maternal serum

A

Down syndrome or other chromosomal abnormality

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30
Q

Degeneration of dorsal column nerves

A

Tabes dorsalis (Tertiary syphilis)

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31
Q

Depigmentation of neurons in substantia nigra

A

Parkinson’s disease (basal ganglia disorder: rigidity, resting tremor, bradykinesia)

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32
Q

Desquamated epithelium casts in sputum

A

Curschmann’s spirals (bronchial asthma; can result in whorled mucous plugs)

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33
Q

Disarrayed granulosa cells in eosinophilic fluid

A

Call-Exner bodies (granulosa-theca cell tumor of the ovary)

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34
Q

Dysplastic squamous cervical cells with nuclear enlargement and hyperchromasia

A

Koilocytes (HPV: predisposes to cervical cancer)

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35
Q

Enlarged cells with intranuclear inclusion bodies

A

“Owl’s eye” appearance of CMV

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36
Q

Enlarged thyroid cells with ground-glass nuclei

A

“Orphan Annie” eye nuclei (papillary carcinoma of the thyroid)

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37
Q

Eosinophilic cytoplamsic inclusion in liver cell

A

Mallory bodies (alcoholic liver disease)

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38
Q

Eosinophilic cytoplasmic inclusion in nerve cell

A

Lewy body (Parkinson’s disease)

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39
Q

Eosinophilic globule in liver

A

Councilman body (toxic or viral hepatitis, often yellow fever)

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40
Q

Eosinophilic inclusion bodies in cytoplasm of hippocampal nerve cells

A

Rabies virus (Lyssavirus)

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41
Q

Extracellular amyloid deposition in gray matter of brain

A

Senile plaques (Alzheimer’s disease)

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42
Q

Giant B cells with bilobed nuclei with prominent inclusions (“owl’s eye”)

A

Reed-Sternberg cells (Hodgkin’s lymphoma)

43
Q

Glomerulus-like structure surrounding vessel in germ cells

A

Schiller-Duval bodies (yolk sac tumor)

44
Q

“Hair-on-end” (crew-cut) appearance on x-ray

A

Beta-thalassemia, sickle cell anemia (marrow expansion)

45
Q

hCG elevated

A

Choriocarcinoma, hydatidiform mole (occurs with and without embryo)

46
Q

Heart nodules (granulomatous)

A

Aschoff bodies (rheumatic fever)

47
Q

Heterophile antibodies

A

Infectious mononucleosis (EBV)

48
Q

Hexagonal, double-pointed, needle-like crystals in bronchial secretions

A

Bronchial asthma (Charcot-Leyden crystals: eosinophilic granules)

49
Q

High level of D-dimers

A

DVT, pulmonary embolism, DIC

50
Q

Hilar lymphadenopathy, peripheral granulomatous lesion in middle or lower lung lobes (can calcify)

A

Ghon complex (Primary TB: Mycobacterium bacilli)

51
Q

“Honeycomb lung” on x-ray

A

Interstitial fibrosis

52
Q

Hypersegmented neutrophils

A

Megaloblastic anemia (B12 deficiency: neurologic symptoms; folate deficiency: no neurologic symptoms)

53
Q

Amy Loves you!!

A

Very very much :)

54
Q

Hypochromic, microcytic anemia

A

Iron deficiency anemia, lead poisoning, thalassemia (HbF sometimes present)

55
Q

Increased alpha-fetoprotein in amniotic fluid/maternal serum

A

Dating error, anencephaly, spina bifida (neural tube defects)

56
Q

Increased uric acid levels

A

Gout, Lesch-Nyhan syndrome, tumor lysis syndrome, loop and thiazide diuretics

57
Q

Intranuclear eosinophilic droplet-like bodies

A

Cowdry type A bodies (HSV or CMV)

58
Q

Iron-containing nodules in alveolar septum

A

Ferruginous bodies (asbestosis: increased chance of mesothelioma)

59
Q

Large lysosomal vesicles in phagocytes, immunodeficiency

A

Chediak-Higashi disease (congenital failure of phagolysosome formation)

60
Q

“Lead pipe” appearance of colon on x-ray

A

Ulcerative colitis (loss of haustra)

61
Q

Linear appearance of glomeruli on immunofluorescence

A

Goodpasture’s syndrome

62
Q

Low serum ceruloplasmin

A

Wilson’s disease (hepatolenticular degeneration)

63
Q

“Lumpy-bumpy” appearance of glomeruli on immunofleorescence

A

Poststreptococcal glomerulonephritis (immune complex deposition of IgG and C3b)

64
Q

Lytic (“hole-punched”) bone lesions on x-ray

A

Multiple myeloma

65
Q

Mammary gland (“blue-domed”) cyst

A

Fibrocystic change of the breast

66
Q

Monoclonal antibody spike (4 things)

A
  1. Multiple myeloma (called the M protein; usually IgG or IgA); 2. Monoclonal gammopathy of undetermined significance (MGUS; normal consequence of aging); 3. Waldenstrom’s (M protein= IgM) macroglobulinemia; 4. Primary amyloidosis
67
Q

Monoclonal globulin protein in blood/urine

A

Bence Jones proteins (multiple myeloma [kappa or lambda Ig light chains in urine]:, Waldenstrom’s macroglobulinemia (IgM)

68
Q

Mucin-filled cell with peripheral mucleus

A

Signet ring (gastric carcinoma)

69
Q

Narrowing of bowel lumen on barium radiograph

A

“String sign” (Crohn’s disease)

70
Q

Needle-shaped, negatively birefringent crystals

A

Gout (monosodium urate crystals)

71
Q

Nodular hyaline deposits in glomeruli

A

Kimmelstiel-Wilson nodules (diabetic nephropathy)

72
Q

Novobiocin response

A

Sensitive: Staphylococcus epidermidis; resistant: Staphylococcus saprophyticus

73
Q

“Nutmeg” appearance of liver

A

Chronic passive congestion of liver due to right heart failure

74
Q

“Onion-skin” periosteal reaction

A

Ewing’s sarcoma (malignant round-cell tumor)

75
Q

Optochin response

A

Sensitive: Streptococcus pneumoniae; resistant: Viridans streptococcus

76
Q

Periosteum raised from bone, creating triangular area

A

Codman’s triangle on x-ray (osteosarcoma, Ewing’s sarcoma, pyogenic osteomyelitis

77
Q

Podocyte fusion on EM

A

Minimal change disease (child with nephrotic syndrome)

78
Q

Polished, “ivory-like” appearance of bone at cartilage erosion

A

Eburnation (osteoarthritis resulting in bony sclerosis)

79
Q

Protein aggregates in neurons from hyperphosphorylation of protein tau

A

Neurofibrillary tangles (Alzheimer’s disease and CJD)

80
Q

Pseudopalisading tumor cells on brain biopsy

A

Glioblastoma multiforme

81
Q

RBC casts in urine

A

Acute glomerulonephritis

82
Q

Rectangular, crystal-like, cytoplasmic inclusion in Leydig cells

A

Reinke crystals (Leydig cell tumor)

83
Q

Renal epithelial casts in urine

A

Acute toxic/viral nephrosis

84
Q

Rhomboid crystals, positively birefringent

A

Pseudogout (calcium pyrophosphate dihydrate)

85
Q

Rib notching

A

Coarctation of the aorta

86
Q

Ring-enhancing brain lesion in AIDS

A

Toxoplasma gondii

87
Q

Sheets of medium-sized lymphoid cells (“starry sky” appearance on histology)

A

Burkitt’s lymphoma (t[8:14] c-myc activation, associated with EBV; “black sky” made up of malignant cells)

88
Q

Silver-staining spherical aggregation of tau proteins in neurons

A

Pick bodies (Pick’s disease: progressive dementia, changes in personality)

89
Q

“Soap bubble” in femur or tibia on x-ray

A

Giant cell tumor of bone (generally benign)

90
Q

“Spikes” on basement membrane, “dome-like” subepithelial deposits

A

Membranous glomerulonephritis (may progress to nephrotic syndrome)

91
Q

Stacks of red blood cells

A

Rouleaux formation (high ESR, multiple myeloma)

92
Q

Stippled vaginal epithelial cells

A

“clue cells” Gardnerella vaginalis)

93
Q

“Tennis-racket”-shaped cytoplasmic organelles (EM) in Langerhans cells

A

Birbeck granules (histiocytosis X: eosinophilic granuloma)

94
Q

Thrombi made of white/red layers

A

Lines of Zahn (arterial thrombus, layers of platelets/RBCs)

95
Q

“Thumb sign” on lateral x-ray

A

Epiglottitis (Haemophilus influenzae)

96
Q

Thyroid-like appearance of kidney

A

Chronic bacterial pyelonephritis

97
Q

“Tram-track” appearance on LM

A

Membranoproliferative glomerulonephritis

98
Q

Triglyceride accumulation in liver cell vacuoles

A

Fatty liver disease (alcoholic or metabolic syndrome)

99
Q

WBCs that look “smudged”

A

CLL (almost always B cell; affects the elderly)

100
Q

“wire loop” glomerular appearance on LM

A

Lupus nephropathy

101
Q

Yellow CSF

A

Xanthochromia (previous subarachnoid hemorrhage)

Rapid Review STEP 1 (13 decks)

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