Neuro/Psych drugs Flashcards
Latanoprost (mechanism and use)
PGF2a -> increases outflow of aq humor
For glaucoma
Latanoprost (side effect)
Darkens color of iris (browning)
Morphine (mechanism)
Opioid analgesics -> G protein linked -> opens K+ channels to increase efflux and closes Ca2+ channels in postsynaptic neurons -> decreases synaptic transmission
Inhibits release of ACh, NE, 5-HT, glutamate, substance P
Morphine (3 uses)
Pain
Pulm edema
Used w/ other CNS depressants during general anesthesia
Morphine (side effects)
Opioid overdose stuff (resp depression, constipation, miosis)
Tolerance doesn’t develop to miosis and constipation
Fentanyl (mechanism)
Opioid analgesics -> G protein linked -> opens K+ channels to increase efflux and closes Ca2+ channels in postsynaptic neurons -> decreases synaptic transmission
Inhibits release of ACh, NE, 5-HT, glutamate, substance P
Fentanyl (3 uses)
Pain
Pulm edema
Used w/ other CNS depressants during general anesthesia
Fentanyl (side effects)
Opioid overdose stuff (resp depression, constipation, miosis)
Tolerance doesn’t develop to miosis and constipation
Codeine (mechanism)
Opioid analgesics -> G protein linked -> opens K+ channels to increase efflux and closes Ca2+ channels in postsynaptic neurons -> decreases synaptic transmission
Inhibits release of ACh, NE, 5-HT, glutamate, substance P
Codeine (2 uses)
Pain
Pulm edema
Codeine (side effects)
Opioid overdose stuff (resp depression, constipation, miosis)
Tolerance doesn’t develop to miosis and constipation
Loperamide (mechanism)
Opioid analgesics -> G protein linked -> opens K+ channels to increase efflux and closes Ca2+ channels in postsynaptic neurons -> decreases synaptic transmission
Inhibits release of ACh, NE, 5-HT, glutamate, substance P
Loperamide (3 uses)
Diarrhea
Pain
Pulm edema
Loperamide (side effects)
Opioid overdose stuff (resp depression, constipation, miosis)
Tolerance doesn’t develop to miosis and constipation
Methadone (mechanism)
Opioid analgesics (mu receptor agonist) -> G protein linked -> opens K+ channels to increase efflux and closes Ca2+ channels in postsynaptic neurons -> decreases synaptic transmission Inhibits release of ACh, NE, 5-HT, glutamate, substance P
Methadone (3 uses)
Maintenance program for heroin addicts (b/c it has longer HL than heroin)
Pain
Pulm edema
Methadone (side effects)
Opioid overdose stuff (resp depression, constipation, miosis)
Tolerance doesn’t develop to miosis and constipation
Meperidine (mechanism)
Opioid analgesics -> G protein linked -> opens K+ channels to increase efflux and closes Ca2+ channels in postsynaptic neurons -> decreases synaptic transmission
Inhibits release of ACh, NE, 5-HT, glutamate, substance P
Meperidine (2 uses)
Pain
Pulm edema
Meperidine (side effects)
Opioid overdose stuff (resp depression, constipation, miosis)
Reduces seizure threshold
Decrease dose w/ renal dysfx
Tolerance doesn’t develop to miosis and constipation
Dextromethorphan (mechanism)
Opioid analgesics -> G protein linked -> opens K+ channels to increase efflux and closes Ca2+ channels in postsynaptic neurons -> decreases synaptic transmission
Inhibits release of ACh, NE, 5-HT, glutamate, substance P
Dextromethorphan (3 uses)
Cough suppression
Pain
Pulm edema
Dextromethorphan (side effects)
Opioid overdose stuff (resp depression, constipation, miosis)
Tolerance doesn’t develop to miosis and constipation
Diphenoxylate (mechanism)
Opioid analgesics -> G protein linked -> opens K+ channels to increase efflux and closes Ca2+ channels in postsynaptic neurons -> decreases synaptic transmission
Inhibits release of ACh, NE, 5-HT, glutamate, substance P