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Drug rxns Flashcards

1
Q

Coronary vasospasm

A

cocaine, sumatriptan (serotonin agonist), ergot alkaloids

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2
Q

Cutaneous flushing

A

“VANC”

vancomycin, adenosine, niacin, CCB

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3
Q

Dilated cardiomyopathy

A

doxorubicine, daunorubicin

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4
Q

TdP

A

class III and IA antiarrhyhmics, macrolides, antipsycotics, TCAs

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5
Q

Adrenocortical insufficiency

A

glucocorticoid withdrawal (creates 2ndary HPA suppression)

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6
Q

Hot flashes

A

tamoxifen, clomiphene

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7
Q

Hyperglycemia

A

“Taking Pills Necessitates Having Blood Checked”

Tacrolimus, Protease inhibitors, Niacin, HCTZ, B-blockers, Corticosteroids

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8
Q

Hypothyroidisim

A

lithium, amiodarone, sulfonamides

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9
Q

Acute cholestatic hepatitis, jaundice

A

erythromycin

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10
Q

Diarrhea

A

“Might Excite Colon On Accident”

Metformin, Erythromycin, Cholchicine, Orlistat, Acarbose

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11
Q

Focal/massive hepatic necrosis

A

“liver HAVAc”

Halothane, Amanita phalloides (death cap mushroom), Valproic acid, Acetaminophen

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12
Q

Hepatitis

A

INH

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13
Q

Pancreatitis

A

“Drugs Causing A Violent Abdominal Distress”

Didanosine, Corticosteroids, Alcohol, Valproic acid, Azathioprine, Diuretics (furosemide, HCTZ)

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14
Q

Pseudomembranous colitis

A

Clindamycin, ampicillin, cephalosporins

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15
Q

Agranulocytosis

A

“Drugs CCCrush Myeloblasts and Promyelocytes”

Dapsone, Clozapine, Carbamazepine, Colchicine, Methimazole, Propylthiouracil

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16
Q

Aplastic anemia

A

“Can’t Make New Blood Cells Properly”

Carbamazepine, Methimazole, NSAIDs, Benzene, Chloramphenicol, Propylthiouracil

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17
Q

Direct Coombs + hemolytic anemia

A

Methyldopa, penicillin

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18
Q

Gray baby syndrome

A

Chloramphenicol (toxic accumulation of metabolites)

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19
Q

Hemolysis in G6PD deficiency

A

“hemolysis IS D PAIN”

INH, Sulfonamides, Dapsone, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin

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20
Q

Megaloblastic Anemia

A

“having a blast with PMS”

Phenytoin, Methotrexate, Sulfa drugs -> all interfere with folate

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21
Q

Thrombocytopenia

A

heparin, cimetidine

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22
Q

Thrombotic complications

A

OCPs

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23
Q

Fat redistribution

A

“Fat PiG”

Protease inhibitor, glucocorticoids

24
Q

Gingival hyperplasia

A

phenytoin, verapamil, cyclosporine, nifedipine

25
Hyperuricemia (gout)
"Painful Tophi and Feet Need Care" | Pyrazinamide, Thiazides, Furosemide, Niacin, Cyclosporine
26
Myopathy
fibrates, niacin, colchicine, hydroxychloroquine, interferon-a, penicillamine, statins, glucocorticoids
27
Osteoporosis
corticosteroids, heparin
28
Photosensitivity
"SAT For Photo" | Sulfonamides, Amiodarone, Tetracycline, 5-FU
29
Rash (Stevens-Johnson syndrome)
"Steven Johnson has epileptic Allergy to Sulfa drugs and Penicillin" anti-epileptic drugs (ethosuximide, carbamazepine, lamotrigine, phenytoin, phenobarbital), Allopurinol, Sulfa drugs, Penicillin
30
SLE-like syndrome
"having lupus is SHIPP-E" Sulfa drugs, hydralazine, INH, Procainamide, Phenytoin, Etanercept Also minocycline and quinidine
31
Teeth discoloration
Tetracyclines
32
Tendonitis, tendon rupture, cartilage damage
fluoroquinolones
33
Cinchonism
quinidine, quinine
34
Parkinson-like syndrome
"cogwheel rigidity of ARM" | Antipsychotics, Reserpine, Metoclopramide
35
Seizures
"with seizures, I BITE My tongue" INH (vit b6 deficiency), Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide Also clozapine and ciprofloxacin
36
Tardive dyskinesia
Antipsychotics, metoclopramide
37
DI
lithium, demeclocycline
38
Fanconi syndrome
expired tetracycline
39
Hemorrhagic cystitis
cyclophosphamide, ifosfamide | prevent by coadministering with mesna
40
Interstitial nephritis
methicillin, NSAIDs, furosemide
41
SIADH
"Can't Concentrate Serum Sodium" | Carbamazepine, Cyclophosphamide, SSRIs
42
Dry cough
ACEi
43
Pulmonary fibrosis
"Breathing Air Badly from Medications" | Bleomycin, Amiodarone, Busulfan, Methotrexate
44
Antimuscarinic
atropine, TCAs, H1-blockers, antipsychotics
45
Disulfiram-like rxn (increased acetaldehyde leading to n/v, headache)
metronidazole, certain cephalosporine, griseofulvin, procarbazine, 1st-gen sulfonylureas
46
Nephrotoxicity/ototoxicity
aminoglycosides, vancomycin, loop diuretics, cisplatin
47
P450 Inducers ("Chronic alcoholic Mona Steals Phen-Phen and Never Refuses Greasy Carbs"
Chronic alcohol use, Modafinil, St. John's wort, Phenytoin, Phenobarbital, Nevirapine, Rifampin, Griseofulvin, Carbamazepine
48
P450 Substrates ("Always Always Always Always Think When Starting Others")
Anti-epileptics, Antidepressants, Antipsychotics, Anesthetics, Theophylline, Warfarin, Statins, OCPs Also metronidazole
49
P450 Inhibitors ("A cute Gentleman "Cipped" Iced Grapefruit juice Quickly And Kept Munching on Soft Cinnamon Rolls")
Acute alcohol abuse, Gemfibrozil, Ciprofloxacin, Isoniazid, Grapefruit juice, Quinidine, Amiodarone, Ketoconazole, Macrolides, Sulfonamides, Cimetidine, Ritonavir Also omeprazole, SSRIs
50
Sulfa drugs
"Popular FACTSSS" | Probenecid, Furosemide, Acetazolamide, Celecoxib, Thiazides, Sulfonamide antibiotics, Sulfasalazine, Sulfonylureas
51
QT Prolongation
``` "Some Risky Meds Can Prolong QT" Sotalol, Risperidone (antipsychotics), Macrolides, Chloroquine, Protease inhibitors, Quinidine (class Ia, also III), Thiazides ```
52
Hepatic granulomatosis
Methyldopa, hydralazine, quinidine
53
Pill-induced esophagitis
Tetracycline, potassium chloride, bisphosphonates
54
Cholesterol gallstone
Fibrates, octreotide, ceftriaxone
55
Cold extremities resulting in Raynaud's phenomenon
B-blockers, ergotamine
56
Gynecomastia
"Some Dope Drugs Easily Create Awkward Hairy DD Knockers" | Spironolactone, marijuana, Digitalis, Estrogen, Cimetidine, Alcohol, Heroin, Dopamine, D2 antagonists, Ketoconazole
57
Transitional cell carcinoma
"Pee SAC" | Phenacetin, Smoking, Aniline dyes, Cyclophosphamide

Pharmacology (12 decks)

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