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Pharmacology > Drug rxns > Flashcards

Drug rxns Flashcards

1
Q

Coronary vasospasm

A

cocaine, sumatriptan (serotonin agonist), ergot alkaloids

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2
Q

Cutaneous flushing

A

“VANC”

vancomycin, adenosine, niacin, CCB

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3
Q

Dilated cardiomyopathy

A

doxorubicine, daunorubicin

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4
Q

TdP

A

class III and IA antiarrhyhmics, macrolides, antipsycotics, TCAs

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5
Q

Adrenocortical insufficiency

A

glucocorticoid withdrawal (creates 2ndary HPA suppression)

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6
Q

Hot flashes

A

tamoxifen, clomiphene

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7
Q

Hyperglycemia

A

“Taking Pills Necessitates Having Blood Checked”

Tacrolimus, Protease inhibitors, Niacin, HCTZ, B-blockers, Corticosteroids

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8
Q

Hypothyroidisim

A

lithium, amiodarone, sulfonamides

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9
Q

Acute cholestatic hepatitis, jaundice

A

erythromycin

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10
Q

Diarrhea

A

“Might Excite Colon On Accident”

Metformin, Erythromycin, Cholchicine, Orlistat, Acarbose

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11
Q

Focal/massive hepatic necrosis

A

“liver HAVAc”

Halothane, Amanita phalloides (death cap mushroom), Valproic acid, Acetaminophen

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12
Q

Hepatitis

A

INH

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13
Q

Pancreatitis

A

“Drugs Causing A Violent Abdominal Distress”

Didanosine, Corticosteroids, Alcohol, Valproic acid, Azathioprine, Diuretics (furosemide, HCTZ)

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14
Q

Pseudomembranous colitis

A

Clindamycin, ampicillin, cephalosporins

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15
Q

Agranulocytosis

A

“Drugs CCCrush Myeloblasts and Promyelocytes”

Dapsone, Clozapine, Carbamazepine, Colchicine, Methimazole, Propylthiouracil

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16
Q

Aplastic anemia

A

“Can’t Make New Blood Cells Properly”

Carbamazepine, Methimazole, NSAIDs, Benzene, Chloramphenicol, Propylthiouracil

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17
Q

Direct Coombs + hemolytic anemia

A

Methyldopa, penicillin

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18
Q

Gray baby syndrome

A

Chloramphenicol (toxic accumulation of metabolites)

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19
Q

Hemolysis in G6PD deficiency

A

“hemolysis IS D PAIN”

INH, Sulfonamides, Dapsone, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin

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20
Q

Megaloblastic Anemia

A

“having a blast with PMS”

Phenytoin, Methotrexate, Sulfa drugs -> all interfere with folate

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21
Q

Thrombocytopenia

A

heparin, cimetidine

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22
Q

Thrombotic complications

A

OCPs

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23
Q

Fat redistribution

A

“Fat PiG”

Protease inhibitor, glucocorticoids

24
Q

Gingival hyperplasia

A

phenytoin, verapamil, cyclosporine, nifedipine

25
Q

Hyperuricemia (gout)

A

“Painful Tophi and Feet Need Care”

Pyrazinamide, Thiazides, Furosemide, Niacin, Cyclosporine

26
Q

Myopathy

A

fibrates, niacin, colchicine, hydroxychloroquine, interferon-a, penicillamine, statins, glucocorticoids

27
Q

Osteoporosis

A

corticosteroids, heparin

28
Q

Photosensitivity

A

“SAT For Photo”

Sulfonamides, Amiodarone, Tetracycline, 5-FU

29
Q

Rash (Stevens-Johnson syndrome)

A

“Steven Johnson has epileptic Allergy to Sulfa drugs and Penicillin”

anti-epileptic drugs (ethosuximide, carbamazepine, lamotrigine, phenytoin, phenobarbital), Allopurinol, Sulfa drugs, Penicillin

30
Q

SLE-like syndrome

A

“having lupus is SHIPP-E”
Sulfa drugs, hydralazine, INH, Procainamide, Phenytoin, Etanercept
Also minocycline and quinidine

31
Q

Teeth discoloration

A

Tetracyclines

32
Q

Tendonitis, tendon rupture, cartilage damage

A

fluoroquinolones

33
Q

Cinchonism

A

quinidine, quinine

34
Q

Parkinson-like syndrome

A

“cogwheel rigidity of ARM”

Antipsychotics, Reserpine, Metoclopramide

35
Q

Seizures

A

“with seizures, I BITE My tongue”
INH (vit b6 deficiency), Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide
Also clozapine and ciprofloxacin

36
Q

Tardive dyskinesia

A

Antipsychotics, metoclopramide

37
Q

DI

A

lithium, demeclocycline

38
Q

Fanconi syndrome

A

expired tetracycline

39
Q

Hemorrhagic cystitis

A

cyclophosphamide, ifosfamide

prevent by coadministering with mesna

40
Q

Interstitial nephritis

A

methicillin, NSAIDs, furosemide

41
Q

SIADH

A

“Can’t Concentrate Serum Sodium”

Carbamazepine, Cyclophosphamide, SSRIs

42
Q

Dry cough

A

ACEi

43
Q

Pulmonary fibrosis

A

“Breathing Air Badly from Medications”

Bleomycin, Amiodarone, Busulfan, Methotrexate

44
Q

Antimuscarinic

A

atropine, TCAs, H1-blockers, antipsychotics

45
Q

Disulfiram-like rxn (increased acetaldehyde leading to n/v, headache)

A

metronidazole, certain cephalosporine, griseofulvin, procarbazine, 1st-gen sulfonylureas

46
Q

Nephrotoxicity/ototoxicity

A

aminoglycosides, vancomycin, loop diuretics, cisplatin

47
Q

P450 Inducers (“Chronic alcoholic Mona Steals Phen-Phen and Never Refuses Greasy Carbs”

A

Chronic alcohol use, Modafinil, St. John’s wort, Phenytoin, Phenobarbital, Nevirapine, Rifampin, Griseofulvin, Carbamazepine

48
Q

P450 Substrates (“Always Always Always Always Think When Starting Others”)

A

Anti-epileptics, Antidepressants, Antipsychotics, Anesthetics, Theophylline, Warfarin, Statins, OCPs

Also metronidazole

49
Q

P450 Inhibitors (“A cute Gentleman “Cipped” Iced Grapefruit juice Quickly And Kept Munching on Soft Cinnamon Rolls”)

A

Acute alcohol abuse, Gemfibrozil, Ciprofloxacin, Isoniazid, Grapefruit juice, Quinidine, Amiodarone, Ketoconazole, Macrolides, Sulfonamides, Cimetidine, Ritonavir

Also omeprazole, SSRIs

50
Q

Sulfa drugs

A

“Popular FACTSSS”

Probenecid, Furosemide, Acetazolamide, Celecoxib, Thiazides, Sulfonamide antibiotics, Sulfasalazine, Sulfonylureas

51
Q

QT Prolongation

A 
"Some Risky Meds Can Prolong QT"
Sotalol, Risperidone (antipsychotics), Macrolides, Chloroquine, Protease inhibitors, Quinidine (class Ia, also III), Thiazides
52
Q

Hepatic granulomatosis

A

Methyldopa, hydralazine, quinidine

53
Q

Pill-induced esophagitis

A

Tetracycline, potassium chloride, bisphosphonates

54
Q

Cholesterol gallstone

A

Fibrates, octreotide, ceftriaxone

55
Q

Cold extremities resulting in Raynaud’s phenomenon

A

B-blockers, ergotamine

56
Q

Gynecomastia

A

“Some Dope Drugs Easily Create Awkward Hairy DD Knockers”

Spironolactone, marijuana, Digitalis, Estrogen, Cimetidine, Alcohol, Heroin, Dopamine, D2 antagonists, Ketoconazole

57
Q

Transitional cell carcinoma

A

“Pee SAC”

Phenacetin, Smoking, Aniline dyes, Cyclophosphamide

Pharmacology (12 decks)

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