Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Adrenergic Agents > Flashcards

Adrenergic Agents Flashcards

1
Q

Epinephrine (mechanism)

A

Stimulates a1, a2, b1, b2 (b > a)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Norepinephrine (mechanism)

A

Stimulates a1 > a2 > b1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Epinephrine (4 uses)

A

Anaphylaxis
Open angle glaucoma
Asthma
For severe hypotension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Norepinephrine (use)

A

For severe hypotension (but decreases renal perfusion)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Isoproterenol (mechanism)

A

Nonselective b-agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Isoproterenol (use)

A

For evaluation of tachyarrhythmias (specifically in hemodynamically stable TdP to increase sinus rate and shorten QT interval)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Isoproterenol (side effects)

A

Can precipitate tachyarrhythmias and worsen ischemia (increases risk of MI)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Dopamine (mechanism)

A

Stimulates D1 = D2 > b > a

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Dopamine (3 uses concerning heart)

A

Unstable bradycardia
CHF
Cardiogenic shock

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Dopamine (side effect)

A

Arrhythmias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Dobutamine (mechanism)

A

b1 agonist -> increases HR, contractility, conduction velocity, myocardial O2 consumption
Also decreases peripheral vascular resistance by having a little bit of b2 effect too

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Dobutamine (2 uses)

A

CHF (inotropic > chronotropic)

Cardiac stress testing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Dobutamine (side effect)

A

Arrhythmias (b/c it increases cardiac conduction velocity)

Angina (b/c it increases myocardial O2 consumption by increasing HR and having positive inotropic effect)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Phenylephrine (mechanism)

A

Stimulates a1 > a2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Phenylephrine (4 uses)

A

Hypotension (vasopressor)
Mydriatic
Reduces secretion (so decongestant for rhinitis, hyperemia, edema)
Open obstructed eustachian tubes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Albuterol (mechanism)

A

Stimulates b2 > b1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Albuterol (use)

A

Acute asthma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

“-terol” (mechanism)

A

Salmeterol and formoterol

Stimulates b2 > b1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

“-terol” (2 uses)

A

Salmeterol and formoterol
Long-term asthma
Long-term COPD control

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Terbutaline (mechanism)

A

Stimulates b2 > b1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Terbutaline (use)

A

Reduces premature uterine contractions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Amphetamine (mechanism)

A

Increases NE by being agonist, reuptake inhibitor, and causing release of stored NE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Amphetamine (3 uses)

A

ADHD
Obesity
Narcolepsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Ephedrine (mechanism)

A

Increases NE by being agonist and causing release of stored NE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Ephedrine (3 uses)
Nasal decongestion Urinary incontinence Hypotension
26
Cocaine (mechanism)
Reuptake inhibitor of catecholamines & general agonist
27
Cocaine (never use with)
b-blockers if cocaine intoxication is suspected -> unopposed a1 activation -> extreme HTN
28
Cocaine (use)
Local anesthetic
29
Difference between effects of NE and isoproterenol on HR
NE has a effects whereas isoproterol doesn't | So NE causes reflex bradycardia (a1-mediated), isoproterenol causes increased HR (b1-mediated)
30
Difference between effects of NE and isoproterenol on BP
NE has a effects whereas isoproterol doesn't | So NE causes increase in BP (a1-mediated), isoproterenol causes decrease in BP (b2-mediated)
31
Clonidine (mechanism)
a2-agonist (sympatholytic)
32
Clonidine (3 uses)
HTN urgency (doesn't decrease renal BF) ADHD Severe pain Off-label for ethanol/opioid withdrawal
33
Clonidine (side effects)
Rebound HTN if stopped immediately CNS & resp depression Pro sympa stuff (bradycardia, hypotension, small pupil)
34
Methyldopa (mechanism)
a2-agonist (analog of L-dopa that gets converted in brain to methyl-NE)
35
Methyldopa (use)
HTN in pregnancy (safe to use in pregnancy)
36
Methyldopa (side effects)
Hemolytic anemia (direct Coombs +) SLE-like syndrome Hepatotoxicity
37
Phenoxybenzamine (mechanism)
Nonselective a-blocker (irreversible) -> dose-response curve shifted right and down (rather than just shifted right like the other REVERSIBLE a blocker) -> can look like noncompetitive binding
38
Phenoxybenzamine (use)
Pre-op pheochromocytoma resection (prevents catecholamines crisis)
39
Phenoxybenzamine (side effects)
Orthostatic hypotension, reflex tachycardia
40
Phentolamine (mechanism)
Nonselective competitive a-blocker (reversible)
41
Phentolamine (3 uses)
``` MAOI crisis (pts on MAOi who eat tyramine-containing foods) Cocaine overdose Pheochromocytoma ```
42
Phentolamine (side effects)
Orthostatic hypotension, reflex tachycardia
43
Prazosin and other "-osin" (mechanism)
a1-blocker
44
Prazosin and other "-osin" (use)
Urinary sx of BPH (esp tamsulosin) Prozosin also used for PTSD All used for HTN except tamsulosin
45
Prazosin and other "-osin" (side effects)
1st-dose orthostatic hypotension | dizziness, headache
46
Mirtazapine (mechanism)
Atypical antidepressant a2-blocker -> increases release of NE and 5-HT Potent 5-HT2 and 5-HT3 ANTAgonist
47
Mirtazapine (use)
Depression
48
Mirtazapine (side effects)
Sedation (desirable in depressed pts w/ insomnia tho), Increases appetite and weight gain, increases serum cholesterol Dry mouth
49
Yohimbine (mechanism)
a2-blocker
50
Yohimbine (historic use)
erectile dysfx (replaced by PDE inhibitors now)
51
B1-blockers
A-M (first half of alphabet, ending in "-olol") | acebutolol (partial agonist), atenolol, betaxolol, esmolol, metoprolol
52
Nonselective b-blockers
N-Z (second half of alphabet, ending in "-olol") nadolol, pindolol (partial agonist), propanolol, timolol More side effects from b2 blockade (bronchoconstriction in lungs)
53
Nonselective a & b blockers
Things with modified suffix carvedilol, lavetalol Also get decreased SVR from a blockade
54
Nebivolol (mechanism)
``` Blocks b1 (cardiac) Stimulates b3 (activates NO synthase in vasculature) ```
55
Timolol (use)
Glaucoma (reduces aq humor secretion)
56
Metoprolol (use)
SVT (reduces conduction velocity - class II antiarrhythmic -> prolongs PR interval)
57
Esmolol (use)
``` SVT (reduces conduction velocity - class II antiarrhythmic -> prolongs PR interval) Acute HTN emergency (ultra short acting) ```
58
B blockers (antidote)
Glucagon
59
B blockers (side effect)
Blunted response to hypoglycemia (dangerous in diabetics bc mask sx of hypoglycemia) -> selective B1 blockers preferable in DM over nonselective Don't use in suspected cocaine users (unopposed a-adrenergic activity) Hyperkalemia w/ nonselective b blockers (interferes w/ B2 mediated intracellular K+ uptake)
60
Partial B agonists
Pindolol | Acebutolol
61
Partial B agonists (contraindication)
Angina
62
Metoprolol (side effect)
Dyslipidemia
63
Propanolol (side effect)
Exacerbate vasospasm in Prinzmetal angina
64
Pseudoephedrine (mechanism)
a agonist
65
Pseudoephedrine (3 uses)
``` Reduces secretions (hyperemia, edema, nasal congestion) Open obstructed eustachian tubes Illicitly used to make methamphetamine ```
66
Pseudoephedrine (2 side effects)
HTN | CNS stimulation/anxiety
67
Carteolol (mechanism and use)
``` B blocker -> decreases aq humor synthesis For glaucoma (no pupillary/vision changes) ```
68
Brimonidine (mechanism)
a2 agonist -> decreases aq humor synthesis
69
Brimonidine (use)
Glaucoma
70
Brimonidine (side effects)
Eyes stuff: blurry vision, hyperemia, foreign body sensation/pruritus, allergic rxn
71
Betaxolol (mechanism and use)
``` B blocker -> decreases aq humor synthesis For glaucoma (no pupillary/vision changes) ```
72
Propanolol (3 uses)
Essential/familial tremors Migraine prophylaxis Reduction of portal venous pressure (to prevent variceal bleed) Other more obvious things

Pharmacology (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions