(neuro) cortical organisation & function Flashcards

1
Q

what is the cerebral cortex?

A

layer that is a couple millimetres thick that covers the entire surface of the brain

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2
Q

describe the structural features of the cerebral cortex

A

contains grey matter (cerebral cortex AND deep grey matter nuclei)

made up of gyri and sulci (highly folded)

lobed

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3
Q

what are fissures?

A

large sulci that separate the cerebrum into lobes

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4
Q

differentiate between fissures and sulci

A

sulci are depression in the cerebral cortex

fissures are larger and deeper depressions that separate the cerebrum into lobes

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5
Q

how is the cerebral cortex microscopically organised?

A

organised into layers and columns

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6
Q

what is Brodmann’s cytoarchitecture?

A

approx 52 regions of the brain classified depending on cell type, cell packing, cell spacing and cell function etc

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7
Q

name the four lobes of the brain

A

frontal, parietal, occipital and temporal

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8
Q

what are the main functions of the frontal lobe?

A

contains primary motor cortex (regulating and initiating motor function)

executive functions (e.g. judgement, reasoning, language, memory, attention etc)

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9
Q

what are the main functions of the parietal lobe?

A

contains primary somatosensory cortex (regulates sensation = pain, touch)

interoception (self-perception) and spatial orientation

sensory aspects of language

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10
Q

what are the main functions of the occipital lobe?

A

processing visual information

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11
Q

what are the main functions of the temporal lobe?

A

processing auditory information

emotions and memory

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12
Q

what are the main functions of the limbic lobe?

A

responsible for memory, emotion, motivation, reward and learning

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13
Q

what are the main functions of the insular cortex?

A

visceral sensations

autonomic control

interoception

auditory processing

visual-vestibular integration

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14
Q

where is the insular cortex found?

A

deep within the lateral fissure

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15
Q

what is the internal structure of the cerebrum made up of?

A

made up of grey matter and white matter

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16
Q

what is grey matter?

A

neuronal cell bodies and glial cells

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17
Q

what is white matter?

A

myelinated neuronal axons arranged in tracts

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18
Q

differentiate between white matter and grey matter

A

white matter consists of neuronal axons arraned in tracts whereas grey matter is a collection of neuronal cell bodies and glial cells

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19
Q

what is the function of white matter tracts?

A

connect cortical areas

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20
Q

what are the three types of white matter tracts?

A

association fibres
comissural fibres
projection fibres

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21
Q

what are the three types of white matter tracts?

A

association fibres
commissural fibres
projection fibres

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22
Q

what are association fibres?

A

connect areas within the same hemisphere together

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23
Q

what are commissural fibres?

A

connect homologous structures in the left and right hemispheres toghether

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24
Q

what are projection fibres?

A

connect cortex with lower brain structures (e.g. thalamus, brainstem and spinal cord)

e.g. corticospinal tract

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25
Q

besides the brain where else are commissural fibres found?

A

found in the spinal cord too (connecting homologous right and left structures)

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26
Q

what are the two types of association fibres?

A

short fibres and long fibres

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27
Q

name four examples of association fibres

A

superior longitudinal fasciculus

arcuate fasciculus

inferior longitudinal fasciculus

uncinate fasciculus

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28
Q

what does the superior longitudinal fasciculus connect?

A

the frontal and occipital lobes

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29
Q

what does the inferior longitudinal fasciculus connect?

A

the temporal and occipital lobes

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30
Q

what does the arcuate fasciculus connect?

A

the frontal and temporal lobes

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31
Q

what does the uncinate fasciculus connect?

A

the anterior frontal and temporal lobes

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32
Q

what is a fasciculus?

A

a bundle of fibres

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33
Q

give two examples of commissural fibres in the brain

A

corpus callosum

anterior commissure

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34
Q

what lower brain structures will projection fibres connect the cortex to?

A

thalamus, spinal cord, brain stem etc

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35
Q

what are the two types of projection fibres?

A

afferent or efferent tracts

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36
Q

differentiate between the afferent and efferent tracts of projection fibres

A

projection fibres are made up of afferent and efferent fibres

afferent fibres (tracts) travel towards the cortex

whereas efferent fibres (tracts) travel away from the cortex

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37
Q

why do afferent tracts travel towards the cortex?

A

carry sensory information from various parts of the body to the primary somatosensory cortex in the parietal lobe

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38
Q

why do efferent tracts travel away from the cortex?

A

carry nerve impulses from the primary motor cortex in the frontal lobe to various parts of the body to bring about movement

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39
Q

give examples of projection fibres

A

both corona radiat ana dinternal capsule contain afferent and efferent fibres

1) corona radiata = deeper out to cortex
2) internal capsule = (extension of the corona radiata) fibres converge through internal capsule between thalamus and basal ganglia

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40
Q

what is the corona radiata?

A

bundle of projection fibres that radiate further out to the cortex

(large projection of fibres to larger area)

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41
Q

what is the internal capsule?

A

bundle of projection fibres that converge separating the thalamus and caudate nucleus from the lentiform nucleus

(large projection of fibres to smaller area)

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42
Q

differentiate between primary cortices and secondary/association cortices

A

primary cortices have predictable functions, are organised topographically and have right-left symmetry

HOWEVER

secondary cortices have less predictable functions, are not organised topographically and have weak/absent right-left symmetry

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43
Q

name the primary cortices

A

primary motor cortex
primary somatosensory cortex
primary visual cortex
primary auditory cortex

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44
Q

name the secondary/association cortices

A

secondary motor cortex
secondary somatosensory cortex
secondary visual cortex
secondary auditory cortex

45
Q

how can the function of various cortices be worked out?

A

stimulation during surgery or studying the consequences of lesions to cortex

46
Q

what are the three motor areas of the frontal lobe?

A

primary motor cortex
supplementary area
premotor area

47
Q

what is the function of the primary motor cortex?

A

controls and enables precise, dextrous voluntary movements by providing descending signals

48
Q

what is the function of the supplementary area?

A

involved in planning complex movements (i.e. internally cued)

49
Q

what is the function of the premotor area?

A

involved in planning complex movements (i.e. externally cued)

50
Q

where is the primary motor cortex found?

A

anterior to the central sulcus

51
Q

where is the premotor area found?

A

anterolateral to the primary motor cortex

52
Q

where is the supplementary area found?

A

anteromedial to the primary motor cortex

53
Q

what are the two somatosensory regions in the parietal lobe?

A

primary somatosensory cortex

somatosensory association

54
Q

what is the function of the primary somatosensory cortex?

A

processes somatic sensations (e.g. proprioception, fine touch, pain, vibration, two-point discrimination and temperature)

55
Q

what is the function of the somatosensory association?

A

interpreting the significance of sensory information

awareness of self and personal space

56
Q

where is the primary somatosensory cortex found?

A

posterior to the central sulcus in the parietal lobe

57
Q

where is the somatosensory association found?

A

posterior to the primary somatosensory cortex in the parietal lobe

58
Q

name the types of somatic sensations that the primary somatosensory cortex is responsible for detecting

A
vibration
pain
two-point discrimination
fine touch
proprioception
59
Q

what are the two visual regions in the occipital lobe?

A

primary visual cortex

visual association

60
Q

what is the function of the primary visual cortex?

A

processes visual stimuli

61
Q

what is the function of the visual association?

A

interprets and provides the meaning of visual input

62
Q

what are the two auditory regions in the occipital lobe?

A

primary auditory cortex and auditory association

63
Q

what is the function of the primary auditory cortex?

A

processes auditory stimuli

64
Q

what is the function of the auditory association?

A

interprets and provides the meaning of auditory input

65
Q

name three general association areas

A

prefrontal cortex, Broca’s area and Wernicke’s area

66
Q

what is the function of the prefrontal cortex?

A

responsible for executive functions such as attention, adjusting social behaviour, planning, personality expression and decision making

67
Q

what is the function of the Broca’s area?

A

speech production

68
Q

what is the function of the Wernicke’s area?

A

speech comprehension

69
Q

how would a lesion of the prefrontal cortex present?

A

patient undergoes personality and behaviour changes (+ loss of inhibition)

70
Q

how would a lesion of Broca’s area present?

A

expressive aphasia - poor production/inability to produce speech but comprehension intact

71
Q

how would a lesion of Wernicke’s area present?

A

receptive aphasia - poor comprehension/inability to comprehend speech but production is fine

72
Q

what is the association cortex for Broca’s area?

A

Wernicke’s area

73
Q

how would a frontal lobe lesion present?

A

loss/change in personality

inappropriate behaviour

74
Q

how would a parietal lobe lesion present?

A

contralateral neglect

lack of awareness of self and extrapersonal space on contralateral side

impaired processing and interpretation of somatic sensations

75
Q

how would a temporal lobe lesion present?

A

leads to agnosia (inability to recognise and identify objects)

cannot form new memories

(depending on whether lesion is lateral/medial)

76
Q

what are the two types of lesions to the temporal lobe?

A

lateral temporal lobe lesion

medial temporal lobe lesion

77
Q

what is expressive aphasia?

A

inability/reduced ability to produce speech but comprehension is intact

78
Q

what is receptive aphasia?

A

inability/reduced ability to comprehend speech but production is intact

79
Q

what is expressive aphasia indicative of?

A

lesion to Broca’s area

80
Q

what is receptive aphasia indicative of?

A

lesion to Wernicke’s area

81
Q

how does a lesion of the primary visual cortex present?

A

blindness in the corresponding part of the visual field (inability to process/receive visual stimuli)

82
Q

how does a lesion of the visual association present?

A

deficits in the interpretation of visual information (i.e. prosopagnosia - inability to recognise familiar faces or learn new faces - face blindness)

83
Q

define prosopagnosia

A

inability to recognise familiar faces or learn new faces (face blindness)

84
Q

what is face blindness?

A

prosopagnosia - inability to recognise familiar faces and learn new faces

85
Q

what happens when a primary cortex gets a lesion?

A

stops receiving information

86
Q

what happens when a secondary/association cortex gets a lesion?

A

cannot interpret the meaning of the information being received

87
Q

how do we assess cortical function using imaging?

A

either PET scan or a fMRI

88
Q

what is a PET scan?

A

measures blood flow directly to a brain region

positron emission tomography

89
Q

what is a fMRI scan?

A

measures amount of oxygen in a brain region

functional magnetic resonance imaging

90
Q

how does a PET scan work?

A

radioactive molecules attach to glucose

so regions with more glucose = heightened blood flow = increased radioactive signals = more activity here in these regions comparatively

greater uptake of glucose during specific activity

91
Q

how can cortical function be assessed using encephalography?

A

encephalography (EEG)

magnetoencephalography (MEG)

92
Q

how does encephalography work?

A

measure electrical signals produced by the brain

93
Q

how does magnetoencephalography work?

A

measures magnetic signals produces by the brain

94
Q

what conditions are detected by an EEG?

A

sleep disturbances, epilepsy

95
Q

how is encephalography carried out?

A

numbered electrodes pushed onto scalp to corresponding brain regions and waves mapped out and studied

96
Q

what is the outcome of elcephalography?

A

series of waves that reflect the sequential activation of neural structures along the somatosensory pathways

97
Q

what is transcranial magnetic stimulation (TMS)?

A

stimulation of neurones using electromagentic induction to assess integrity of neural circuits

98
Q

what is transcranial direct current stimulatio (tDCS)?

A

using low direct current to increase or decrease neuronal firing rate

99
Q

what is diffusion tensor imaging (DTI)?

A

imaging based on the diffusion of water molecules

100
Q

what is diffusion tensor imaging (DTI) with tractography?

A

imaging in the form of 3D reconstruction to assess neural tracts

101
Q

how can cortical function be assessed using brain stimulation?

A

TMS (transcranial magnetic stimulation)

tDCS (transcranial direct current stimulation)

102
Q

how can cortical function be assessed using imaging (assessment of structure)?

A

DTI (diffuse tensor imaging)

DTI with tractography

103
Q

what are the four ways cortical function can be assessed?

A

imaging (PET/ fMRI)

brain stimulation (TMS, tDCS)

encephalography (EEG, MEG)

imaging to assess structure (DTI, +tractography)

104
Q

what is the function of white matter tracts?

A

connect cortical regions together

i.e. bundles of myelinated axons

105
Q

how is the cerebral cortex arranged in columns?

A

small pyramidal neurone

stellate neurone

large pyramidal neurone

106
Q

how is the cerebral cortex arranged in layers?

A

layers I-VI

molecular
external granular
external pyramidal
internal granular
internal pyramidal
multiform
107
Q

what are the components of the limbic lobe?

A

amygdala
hippocampus
mammillary body
cingulate gyrus

108
Q

which association fibre connects Broca’s and Wernicke’s areas?

A

arcuate fasciculus

109
Q

which potential types are used in encephalography to evoke a response?

A

visual evoked potentials

event-related potentials

somatosensory evoked potentials