Neuro

Question 1

valproate

Answer 1

na channel blocker, migraines, saturable metabolism, protein binding

Question 2

phenytoin

Answer 2

na channel blocker, saturable metabolism, gingival hyperplasia, hirsutism, nystagmus, purple glove

Question 3

carbamazepine

Answer 3

na channel blocker, autoinducer, aplastic anemia, agranulocytosis, genetic screening, trigeminal neuralgia

Question 4

lamotrigine

Answer 4

na channel inactivation, focal seizures or adjunct to general, titration schedule, autoinducer, rash

Question 5

ethosuximide

Answer 5

ca channel blocker, absence seizures only

Question 6

fosphenytoin

Answer 6

phosphate added, more soluble, prodrug

Question 7

phenobarbital

Answer 7

positive allosteric GABA-A, increased duration of cl channel opening

Question 8

primidone

Answer 8

parent drug of phenobarbital

Question 9

clonazepam

Answer 9

positive allosteric GABA-A, seizure maintenance

Question 10

lorazepam

Answer 10

positive allosteric GABA-A, seizure maintenance

Question 11

oxcarbazepin

Answer 11

less enzyme induction than carbamazepine, focal epilepsy only

Question 12

eslicarbazepine

Answer 12

like oxcarbazepin and carbamazepine, monotherapy and once daily

Question 13

gabapentin

Answer 13

binds ca channels, partial seizure adjunct and post herpatic neuralgia

Question 14

pregabalin

Answer 14

like gabapentin plus diabetic neuropathy, better absorption

Question 15

levetiracetam

Answer 15

binds SV2A, partial seizure adjunct, few contraindications

Question 16

lacosamide

Answer 16

slow na channel inactivation

Question 17

acetazolamide

Answer 17

carbonic anydrase inhibitor, adjunct therapy, reduces CSF pressure

Question 18

zonisamide

Answer 18

na channel blocker with slight carbonic anhydrase inhibition

Question 19

topiramate

Answer 19

na channel blocker plus carbonic anhydrase inhibition and GABA augmentation, tonic-clonic seizures, migraines

Question 20

amitriptyline

Answer 20

TCA for migraines

Question 21

-triptans

Answer 21

5HT1 receptor agonists

Question 22

ergotamine, DHE

Answer 22

migraines

Question 23

baclofen

Answer 23

antispastic, GABA-B agonist

Question 24

cyclobenzaprine

Answer 24

antispastic, similar to TCAs

Question 25

methocarbamol

Answer 25

antispastic, similar to cyclobenzaprine

Question 26

tizanidine

Answer 26

antispastic, alpha 2 agonist

Question 27

dantrolene

Answer 27

antispastic, blocks calcium release from SR, hepatotoxicity

Question 28

diazepam

Answer 28

muscle spasms

Question 29

carisoprodol

Answer 29

barbiturate like, short term antispastic

Question 30

levodopa

Answer 30

dopamine precursor

Question 31

carbidopa

Answer 31

decarboxylase inhibitor, prevents L-dopa metabolsim outside CNS

Question 32

pramipexole

Answer 32

non-ergot DA agonist

Question 33

entacapone

Answer 33

COMT inhibitor, adjunct to L-dopa

Question 34

rasagiline

Answer 34

MAO-B inhibitor, adjunct to L-dopa

Question 35

donepezil

Answer 35

cholinesterase inhibitor, alzheimers

Question 36

ropinorole

Answer 36

non-ergot DA agonist