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Pharm > Neuro > Flashcards

Neuro Flashcards

1
Q

valproate

A

na channel blocker, migraines, saturable metabolism, protein binding

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2
Q

phenytoin

A

na channel blocker, saturable metabolism, gingival hyperplasia, hirsutism, nystagmus, purple glove

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3
Q

carbamazepine

A

na channel blocker, autoinducer, aplastic anemia, agranulocytosis, genetic screening, trigeminal neuralgia

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4
Q

lamotrigine

A

na channel inactivation, focal seizures or adjunct to general, titration schedule, autoinducer, rash

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5
Q

ethosuximide

A

ca channel blocker, absence seizures only

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6
Q

fosphenytoin

A

phosphate added, more soluble, prodrug

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7
Q

phenobarbital

A

positive allosteric GABA-A, increased duration of cl channel opening

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8
Q

primidone

A

parent drug of phenobarbital

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9
Q

clonazepam

A

positive allosteric GABA-A, seizure maintenance

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10
Q

lorazepam

A

positive allosteric GABA-A, seizure maintenance

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11
Q

oxcarbazepin

A

less enzyme induction than carbamazepine, focal epilepsy only

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12
Q

eslicarbazepine

A

like oxcarbazepin and carbamazepine, monotherapy and once daily

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13
Q

gabapentin

A

binds ca channels, partial seizure adjunct and post herpatic neuralgia

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14
Q

pregabalin

A

like gabapentin plus diabetic neuropathy, better absorption

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15
Q

levetiracetam

A

binds SV2A, partial seizure adjunct, few contraindications

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16
Q

lacosamide

A

slow na channel inactivation

17
Q

acetazolamide

A

carbonic anydrase inhibitor, adjunct therapy, reduces CSF pressure

18
Q

zonisamide

A

na channel blocker with slight carbonic anhydrase inhibition

19
Q

topiramate

A

na channel blocker plus carbonic anhydrase inhibition and GABA augmentation, tonic-clonic seizures, migraines

20
Q

amitriptyline

A

TCA for migraines

21
Q

-triptans

A

5HT1 receptor agonists

22
Q

ergotamine, DHE

A

migraines

23
Q

baclofen

A

antispastic, GABA-B agonist

24
Q

cyclobenzaprine

A

antispastic, similar to TCAs

25
Q

methocarbamol

A

antispastic, similar to cyclobenzaprine

26
Q

tizanidine

A

antispastic, alpha 2 agonist

27
Q

dantrolene

A

antispastic, blocks calcium release from SR, hepatotoxicity

28
Q

diazepam

A

muscle spasms

29
Q

carisoprodol

A

barbiturate like, short term antispastic

30
Q

levodopa

A

dopamine precursor

31
Q

carbidopa

A

decarboxylase inhibitor, prevents L-dopa metabolsim outside CNS

32
Q

pramipexole

A

non-ergot DA agonist

33
Q

entacapone

A

COMT inhibitor, adjunct to L-dopa

34
Q

rasagiline

A

MAO-B inhibitor, adjunct to L-dopa

35
Q

donepezil

A

cholinesterase inhibitor, alzheimers

36
Q

ropinorole

A

non-ergot DA agonist

Pharm (10 decks)

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