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Pharm > Heme/Onc > Flashcards

Heme/Onc Flashcards

1
Q

Alkylating agents

A

Prevent DNA unwinding (Nitrogen mustards/platinum analogues, hemorrhagic cystitis with NMs, cold sensitivity with PAs)

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2
Q

Topoisomerase inhibitors

A

Inhibit breaking and rejoining of DNA

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3
Q

Antitumor antibiotics

A

Trialed as antibiotics/act as alkylating agents

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4
Q

Proteosome inhibitors

A

Inhibits protein homeostasis

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5
Q

Tyrosine kinase inhibitors

A

Regulate messenger activity

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6
Q

cyclophosphamide

A

nitrogen mustard

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7
Q

ifosfamide

A

nitrogen mustard

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8
Q

-platin

A

platinum analogues

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9
Q

ironotecan

A

topoisomerase inhibitor (diarrhea)

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10
Q

doxorubican

A

topoisomerase inhibitor (cardiotoxicity)

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11
Q

etoposide

A

topoisomerase inhibitor

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12
Q

vincristine

A

antimicrotubule (fatal intrathecal)

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13
Q

docetaxel

A

antimicrotubule

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14
Q

dexrozoxane

A

prevent anthracycline cardiotoxicity

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15
Q

mesna

A

prevent ifofsamide hemorrhagic cyctitis

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16
Q

paclitaxel

A

antimicrotubule

17
Q

capecitabine

A

antimetabolite

18
Q

cytarabine

A

antimetabolite

19
Q

fluorouracil

A

antimetabolite (mucosal damage)

20
Q

leucovorin

A

reduced form of folic acid, methotrexate toxicity, modulates fluorouracil

21
Q

methotrexate

A

antimetabolite (antifolate)

22
Q

bleomycin

A

antitumor antibiotic (pulmonary fibrosis)

23
Q

bortezomib

A

proteasome inhibitor (herpes reactivation)

24
Q

lenalidomide

A

immunomodulator (birth defects, thromboembolic events)

25
-mab
monoclonal antibodies
26
-nib
tyroskine kinase inhibitors
27
filgrastim
GMCSF
28
pegfilgrastim
GMCSF
29
sargramostim
GMCSF
30
hydroxyurea
ribonucleotide reductase inhibitor
31
azathioprine
purine synthesis inhibitor
32
6-mercatopurine
purine synthesis inhibitor
33
mycophenolate
purine synthesis inhibitor
34
sirolimus
mTOR inhibitor
35
cyclosporine
calcineurin inhibitor
36
tacrolimus
calcineurin inhibitor

Pharm (10 decks)

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