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Pharm > MSK > Flashcards

MSK Flashcards

1
Q

raloxifene

A

SERM, ER agonist in bone and antagonist in uterus and breast, increase bone density

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2
Q

tamoxifen

A

SERM, ER antagonist in breast, agonist in uterus, breast cancer prevention

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3
Q

bazedoxifene

A

SERM, combination with CEE, antagonize uterus and breast, prevent osteoporosis and treat menopause symptoms

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4
Q

finasteride

A

5 alpha reductase inhibitor

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5
Q

flutamide

A

androgen receptor antagonist

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6
Q

anastrozole

A

aromatase inhibitor, inhibit conversion of androgens to estrogens

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7
Q

-statins

A

inhibit cholesterol synthesis

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8
Q

methotrexate

A

anti-folate DMARD, psoriasis, RA, juvenile idiopathic arthritis

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9
Q

leflunomide

A

pyrimidine synthesis inhibitor DMARD, relapsing MS,

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10
Q

hydroxychloroquine

A

DMARD, antimalarial for SLE and RA, eye exams

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11
Q

sulfasalazine

A

DMARD, RA and juvenile RA, better for pregnancy

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12
Q

adalimumab

A

RA, human

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13
Q

infliximab

A

RA, psoriasis, crohns, human-mouse

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14
Q

tofacitinib

A

reduces circulating TNF

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15
Q

colchinine

A

prevents leukocyte migration into joints, gout

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16
Q

allopurinol

A

reduces uric acid formation, don’t start during attack, cataracts

17
Q

probenecid

A

increases uric acid secretion, don’t use during attack

18
Q

-dronates

A

bisphosphonates

19
Q

teriparatide

A

PTH analog, bone formation

20
Q

cinacalcet

A

calcimimetic, suppresses PTH

21
Q

denosumab

A

inhibits osteoclasts

22
Q

propofol

A

promotes GABA release

23
Q

ketamine

A

NMDA antagonist

24
Q

etomidate

A

very fast, CVD patients

25
Q

-anes

A

inhaled anesthetics, GABA agonists

26
Q

NO

A

more analgesia, less anesthesia, NMDA blocker

27
Q

succinylcholine

A

depolarizing NMB

28
Q

-curoniums

A

non-depolarizing NMB

29
Q

neostigmine

A

non-depolarizing NMB reversal, muscarinic agonist

30
Q

ospemifene

A

SERM, antagonist in breast and agonist in bone and vagina

31
Q

clomiphene

A

prevents estrogens negative feedback, ovulation

32
Q

fulvestrant

A

potent estrogen antagonist

Pharm (10 decks)

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