Neuro Flashcards
Causes of dementia
alzheimers chronic ETOH use huntingtons chorea parkinsons hypothyroid pernicious anemia depression normal pressure hydrocephalus bismuth poisoning
ETOH use dementia
malnutrition and thiamin deficiency
Parkinsons etiology and tx
depletion of dopamine –> exaggerated ACh effect
Tx: anticholinergic therapy for tremors/ cholinesterase inhibitors (donepezil, rivastigamine, galantamine)
Huntingtons dz
dementia, chorea
autosomal dominant
Reversible causes of dementia
hypothyroid pernicious anemia depression normal pressure hydrocephalus bismuth poisoning
Most sensitive test for B12 deficieny
serum methylmalonic acid (mma)
Normal pressure hydrocephalus presentaion
dementia
abnormal gait
urinary incontinence/urgency
Cerebellar disease findings
intention tremor
nystagmus
ataxia
dysmetria
Impaired cerebellar fxn can be caused by
multiple sclerosis stroke midbrain tumor mercury poisoining Wilson's disease hereditary cerebellar degeneration
Familial (essential) tremor cause, presentation and tx
- autosomal dominant inheritance
- intention and postural tremor w/ otherwise normal exam
- propranolol
Myasthenia gravis etiology, presentation, diagnosis
- autoimmune disorder
- variable weakness of skeletal muscles
- present of anti-acetylcholine receptor antibody, dx established by response to short acting anticholinesterase
CRP used to:
- assess rick for recurrent ischemic events after CABG or PCI
- Predict future coronary events or stroke
- monitor RA, giant cell arteritis, PMR
Antiphospholipid antibody (APA) syndrome
- can be primary or associated with SLE
- increased risk of thrombosis
- spontaneous abortion in first trimester
- lifelong anticoagulation
Amaurosis fugax
transient, monocular loss of vision for 1-2 mins due to ipsilateral carotid atherosclerotic disease causing retinal emboli
Vertebrobasilar artery insufficiency manifestation
impaired speech, double or blurred vision, vertigo, ataxia, weakness