Heme

Question 1

Hemolysis labs

Answer 1

decreased haptoglobin (heptoglobin binds free Hg)
increased LDH
Increased retic %

Question 2

Polycythemia vera etiology, lab values, and treatment

Answer 2

• overproduction of all blood elements
• normal arterial O2, LOW erythropoietin
• phlebotomy

Question 3

Antinuclear antibodies (ANA) found in:

Answer 3

primary biliary cirrhosis
SLE
RA
Sjogren's syndrome
scleroderma
polymyositis

Question 4

anti-dsDNA sensitive for:

Answer 4

SLE

Question 5

Complications of mono

Answer 5

aseptic meningitis, nell’s palsy, guillian-barre syndrome
hemolytic anemia, neutropenia, thrombocytopenia
rarely- acute pericarditis

Question 6

Mono presentation and diagnosis

Answer 6

• fever, sore throat, malaise, lymphadenopathy, 1/3 have strep pharyngitis
• presence of heterophile ab on Monospot test

Question 7

Tumor lysis syndrome cause, labs, tx

Answer 7

due to rapid tumor cell death with chemo

• hyperkalemia, hyperphosphatemia, hyperuricemia
• can result in ARF
• prophylactic allopurinol and volume expansion (fluids)

Question 8

Causes of macrocytosis

Answer 8

alcohol
liver disease
hypothyroidism

Question 9

hypothyroid assoc w/ what blood disorder

Answer 9

pernicious anemia

Question 10

B12 deficiency lab characteristics

Answer 10

megaloblastic bone marrow
macrocytosis
hypersegmented neutrophils
increased methylmalonic acid

Question 11

causes of B12 deficiency

Answer 11

autoimmune: pernicious anemia, hashimoto’s (10%)

non autoimmune: dietary, gastrectomy, bacterial overgrowth, IBD affecting terminal ileum

Question 12

Pernicious anemia antibody

Answer 12

anti-intrinsic factor Ab

anti-parietal cell Ab

Question 13

Petechiae causes

Answer 13

thrombocytopenia
vasculitis
infections emboli
endocarditis
cholesterol emboli
meds
RMSF