Neural Crest

Question 1

Steel factor is thought to be a chemo-attractant for cells with C-kit and migration of _____ _____ cells

Answer 1

Neural Crest

Question 2

You see deficits in pharyngeal arches, thymus, parathyroid, and outflow tract, with low-set ears and a cleft palate. What do you suspect?

Answer 2

DiGeorge Syndrome, the defects line up with defects with the neural crest migration pathway

Question 3

How do Neural Crest Cells transition from epithelial to mesenchymal cells?

Answer 3

By losing 6B class of cadherins

Question 4

c-Ret and the ligand GDNF are a ligand-receptor pair responsible for migration to the ____ and correspond with the disorder

Answer 4

gut, Hirschsprung’s disease

Question 5

DiGeorge syndrome uses the transcription factor _____ which is a downstream target of Shh and includes FGF genes, which if not knocked out, give the same phenotype.

Answer 5

Tbx-1