Cell-Signaling

Question 1

Gq-Alpha mnemonic

Answer 1

Quick Chekc

Gq-PKC

Question 2

GEF function

Answer 2

Activate GDP to GTP

Question 3

The alpha subunit of the trimeric G-protein gets activated by ______

Answer 3

The 7tm receptor itself (acts as own GEF)

Question 4

Ras, rab, ran, and rac are examples of monomeric _____ _____

Answer 4

G-Proteins

Question 5

Extracellular Vs. Cytoplasmic Domain function for protein kinase receptors

Answer 5

• Ex binds ligand

- Cyto has kinase

Question 6

GAP function

Answer 6

Inactivate GTP to GDP

Question 7

Dimerized Steroid receptors bind to _____ _____ _____, which are DNA promoter regions

Answer 7

Estrogen Response Elements (ERE)

Question 8

They’re called G-Proteins because they bind _____ _____

Answer 8

Guanine Nucleotides

Question 9

Gs-Alpha pathway

Answer 9

AC-cAMP-PKA-Calcium

Question 10

The ______ receptors are the most abundant and use Timeric G-Proteins

Answer 10

7 alpha-helix Receptors

Question 11

Gi-Alpha directly inhibits _____

Answer 11

Adenylate Cyclase

Question 12

Gq-Alpha pathway

Answer 12

Gq-PKC-PPip2–DAG and iP3

“DAG directly unchains the kinase”