Cytoskeleton Flashcards
-Actin - Myosin - Microtubules - Kinesins and Dyenins
How is Dynein different from Myosin and Kinesin?
Dynein binds Cytoskeleton through the Stalk
Phalloidin, Cytochalasin, and Latrunculin are three toxins to which cytoskeletal component?
Actin
Keratins, Neurofilaments, and Nuclear Lamins are all examples of _____ _____, which is one of the three cytoskeletal components
Intermediate Filaments
How many directions does Myosin move in?
One direction
The 3 steps to actin polymerization include _______, which is the RLS, Elongation, and Steady State
Nucleation, whereby 3ATP-Actin come together
What Tri-Phosphate unit do microtubules bind?
GTP
If you were to see 4 coil coil dimers bind in an anti-parallel fashion, which cytoskeleton would you be looking at?
Intermediate Filaments
What Tri-phosphate unit does actin bind?
ATP
Do ATPases or GTPases use hydrolysis
No
Microtubule Dynamic Instability vs Actin Treadmilling
- Mts grow or shrink only on one side
- Act grows faster on one side than the other, but capping and severing occurs on both sides
One cause of Alzheimers is a build up of Tau protein, which normally binds to ____, but instead they fall off and build plaques
Microtubules
Paclitaxel, Colchicine, and Vincristine are toxins to _____
Microtubules
Listeria hijacks ____ to propel itself
Actin
