nervous system: synaptic transmission Flashcards
Junctions between 2 neurons are
postsynaptic and presynaptic
Site where an action potential in one neuron affects the production of an action potential in another neuron
Synapse
2 types of synaptic transmission
electrical synapses and chemical synapses
electrical synapses does what
pass electrical signals, are bidirectional and fast
chemical synapses does what
uses chemical messengers or neurotransmitters
electrical synapses gap junction allows
electrical current to flow between adjacent cells
where is electrical synapses found
cardiac, smooth muscle, and some neurons and glia
chemical synapses- presynaptic terminal
synaptic vesicles contain chemical messenger neurotransmitter (NT)
chemical synapses- synaptic cleft
space between presynaptic and postsynaptic cell, neurotransmitter diffusion
chemical synapses- postsynaptic membrane
neurotransmitter receptors
are chemical synapses mono or bi directional
monodirectional
how are EPSP created
Na channel permeability is increased-> graded depolarization –> neuronal membrane closer together—-> EPSP created
How is IPSP created
K or Cl permeability increased –> graded hyper polarization —-> neuronal membrane potential farther away from threshold —> IPSP
most common inhibitor
GABA
most common excitatory neurotransmitter
glutamate
gaseous neurotransmitter
nitric oxide
Glutamate is removed via ____ with the help of ____
reuptake, glutatamate transporters
glial cells that assist with neurotransmitter removal
astrocytes
2 families of receptors
ionotropic and metabotropic
ligand-gated ion channels that when a ligand binds to the receptor membrane channel will open
ionotropic receptor
7-transmembrane GPCRs, binding of neurotransmitter initiates a second messenger to modulate channel on neural membrane
metatropic receptor
example of inotropic receptor
ligand gated channels-nicotinic cholinergic
example of metatropic channels
GPCRs- muscarinic-cholinergic receptor
GABAa is what type of receptor and GABAb is what type
ionotropic and metatropic
many antidepressants block what to cause what result
neurotransmitter reuptake to increase the neurotransmitter concentration in the synaptic cleft and increased stimulation of correspond post-synaptic receptors