Nephrotic syndrome 12/21 Flashcards
pathoma. how is characterized neohrotic?
proteinuria > 3,5 g/d
pathoma. 4 points about nephrotic
- Hypoalbuminemia –> pitting edema
- Hypogammaglobulinemia -> infection risk
- hypercoagulable state -> loss of ATIII.
- hyperlipidemia and hypercholesterolemia - may result in fatty casts in urine
Hypoalbuminemia –>
Hypoalbuminemia –> pitting edema
Hypogammaglobulinemia ->
Hypogammaglobulinemia -> infection risk
hypercoagulable state ->
Hypercoagulable state -> loss of ATIII, protein C and S.
Also, increased synthesis of fibrinogen
Hyperlipidemia and hypercholesterolemia –>
hyperlipidemia and hypercholesterolemia - may result in fatty casts in urine
Minimal change diseases - causes?
usually idopathic;
may be assoc. with hodgkin lymphoma
LM - normal glomeruli; IF - negative, EM - effacement of podocyte foot processes. What disease?
Minimal change disease.
Most common cause of nephrotic syndrome in children?
Minimal change disease.
minimal change disease - response to steroids?
why?
excellent
because damage is mediated by cytokines from T cells
what proteinuria in minimal change disease?
Selective.
Loss of albimun, but not immunoglobulin
LM - segmental sclerosis and hyalinosis, IF - negative (often), EM - effacement of podocyte foot processes. What disease?
Focal segmental glomerulosclerosis.
Focal glomerular sclerosis causes? 1 and 2.
1 - Idiopatic.
2 - HIV, heroin abuse, sickle cell disease, obesity, interferon treatment, congenital malformations.
What disease is associated with drugs (NSAIDs, penicillamine)?
Membranous nephropathy.
LM - diffuse capillary and GBM thickening without hypercellularity, IF - granular, EM - ,,spike and dome” appearance of subepithelial deposits. What disease?
Membranous nephropathy.
Which of nephoritc syndromes is mediated by immune complexes?
Membranous nephropathy and membranoproliferative GN.
Most common syndrome in African Americans?
Focal segmental glomerulosclerosis.
Membranous nephropathy causes? 1 and 2.
1 - Idiopathic. (In FA 1 is antibodies to phospholipase A2 receptors).
2 - Drugs (NSAIDs, penicillamine, gold), infections (HBV, HCV, syphilis), SLE, tumors.
EM - ,,spike and dome” appearance of subepithelial deposits. What disease?
Membranous nephropathy.
Diabetic glomerulonephropathy mechanism?
Hyperglycemia –> nonenzymatic glycosylation of the vascular basement membrane/ tissue proteins–> hyaline arteriosclerosis/mesangial expansion.
What is Kimmelstiel-Wilson nodules? What disease?
Nodular sclerosis of mesangium in diabetic glomerulonephropathy.
Why there is hyaline arteriosclerosis in diabetic glomerulonephropathy?
Nonenzymatic glycosylation of vascular basement membrane –> hyaline arteriosclerosis.
Which arteriole is more affected by diabetic nephropathy? What effect on glomerul?
Efferent arteriole. It leads to high GF pressure –> hyperfiltration –> glomerular hypertrophy and glomerulosclerosis.
What deposits are in IF of membranous nephropathy?
Granular.
What are disruptions of glomerular charge barrier?
1 - direct sclerosis of podocytes.
2 - systemic process damages podocytes, e.g. diabetes, SLE.
Why there is hypercoagulable state in nephrotic syndrome?
Due to loss of antithrombin III.
Why there is increased risk of infections in nephrotic syndrome?
Due to hypogammaglobulinemia.
What is proteinuria in nephrotic syndrome? ( g/day)
> 3,5 g/day.
What is the difference in pathogenesis of nephritic and nephrotic syndromes?
Nephritic: neutrophil-mediated glomeruli injury.
Nephrotic: T-cell and cytokines damage podocytes to lose their negative charge.
What is the hallmark of neprotic syndrome?
Effacement of podocyte foot processes.
A child with lymphoma. What renal disease is most likely to appear?
Minimal change disease.
What disease can trigger recent infections, immunization or immune stimulus? What is it - primary or secondary reason?
Minimal change disease. Primary.
Which disease has excellent response to corticosteroids?
Minimal change disease.
What disease can provoke sicle cells disease and HIV?
Focal segmental glomerulosclerosis.
African american uses heroin. What renal disease most likely to appear?
Focal segmental glomerulosclerosis.
O patient is treated with interferon. What renal disease most likely to appear?
Focal segmental glomerulosclerosis.
In focal segmental glomerulosclerosis IF usually is negative, but sometimes positive. For what structures it would be positive?
May be positive for nonspecific focal deposits of IgM, C3, C1.
Which 2 diseases have poor response to corticosteroids?
Focal segmental glomerulosclerosis and primary membranous nephropathy.
What disease cause antibodies to phospholipase A2 receptors? Is it primary or secondary reason?
Membranous nephropathy. Primary.
Which two nephrotic syndrome disease may progress to CKD?
Focal segmental glomerulosclerosis and membranous nephropathy.
What changes are seen in GBM affected by hyperglycemia?
GBM thickening and increased permeability.
What changes of glomeruli is caused by hyperfiltration?
Glomerular hypertrophy and glomerular scarring (glomerulosclerosis)
How is stained nodular glomerularsclerosis (Kimmelstiel-Wilson)?
Eosinophilic.
LM - mesangial expansion, GMB thickening, nodular glomerulosclerosis. What disease?
Diabetic glomerulonephropathy.
What states leads to further progression o nephropathy in diabethic glomerulonephropathy?
Glomerular hypertrophy and glomerulosclerosis.
What is seen in LM when diabetic glomerulonephropathy?3
Mesangial expansion, GMB thickening, nodular glomerulosclerosis.