ATN stages lentele UW 12/13

Question 1

3 stages?

Answer 1

Initiation, maintenance, recovery

Question 2

Initiation - duration?

Answer 2

24-36h

Question 3

maintenance - duration?

Answer 3

1-3 weeks

Question 4

recovery - duration?

Answer 4

months

Question 5

Initiation. mechanism?

Answer 5

tubular injury resulting from: Ischemia or toxins

Question 6

Maintenance. What changes?

Answer 6

Oliguric renal failure - decr. GFR, decr. urine output, fluid overload
incr BUN:Cr (cia tas padidejimas del sumazejusio GRF, bet siaip tai nefunkcionuoja lasteles, tai turetu buv <15:1), incr. potassium, incr phosphate, metabolic acidosis
osmol < 350 mOsm
UNa>30, FENa >1 proc.

Question 7

Recovery. What changes?

Answer 7

Gradual increase in urine output - leads to high duresis
continued impairment of tubular function resulting in electrolyte wasting (two arrows down to potassium, Mg, P, Ca).

Question 8

Why there is poliuria?

Answer 8

GFR often improves BEFORE renal tubular function.
Poliuria and electrolyte wasting.