Nephritic syndrome 12/21 Flashcards
LM - enlarged and hypercellular glomeruli, IF - granular, EM - subepitheliam humps. What disease?
Acute PSG.
Pathoma. Nephritic syndrome. glomerular disorders characterized by …. 2
glomerular inflammation and bleeding
Nephritic syndrome. 4 points in pathoma
Limited proteinuria < 3,5g/day
Oliguria and azotemia
Salt retention with periorbital edema and hypertension
RBC casts and dysmorphic RBCs in urine
Pathoma. Biopsy nephritic
hypercellular, inflamed glomeruli
Pathoma. Nephritic. What molecules deposited and what is activated
Immune complex deposition activates complement;
C5a attracts neutrophils, which mediate damage.
In acute PSG what is deposits in EM?
Subepithelial.
What organs infection cause Acute PSG?
Pharynx and skin.
What are 2 serologican changes in acute PSG?
Increased ASO, decreased C3.
What 3 materials form deposits in acute PSG? Where are those deposits?
IgG, IgM, C3. Deposits are along GBM and mesangium.
When is seen acute PSG after A streptococcal infection?
2-4 weeks after infection.
Crescents consist of ……
Fibrin, macrophages, monocytes, glomerulal parietal cells, plasma proteins (C3b)
Rapidly progressive glomerulonephritis: Linear IF. What is mechanism?
Antibodies againts GBM and alveolar basement membrane, e.i. IV type collagen.
Rapidly progressive glomerulonephritis: Negative IF. What is mechanism?
In disease there are no Ig/C3 depositions.
Rapidly progressive glomerulonephritis: Granular IF. What is mechanism?
Immune depositions. IgG, C3, in acute PSG also IgM.
What is the type of hypersinsitivity in Goodpasture syndrome?
II type.
What is the treatment of Goodpasture syndrome?
Plasmapheresis.
What clinical appearance is in Goodpasture syndrome?
Hematuria and hemoptysis.
What ANCA is in Wegener granulomatosis?
c-ANCA/PR3-ANCA
What ANCA is in Microscopic polyangiitis?
p-ANCA/MP-ANCA
What means Pauci immune?
No Ig/C3 depositions (negative IF).
In what diesease are negative IF?
Wegener, microscopic polyangiitis, Churg-Strauss.
What ANCA is in Churg-Strauss?
p-ANCA/MP-ANCA
How to distinguish Churg-Strauss and Microscopic polyangiitis?
In Churg-Strauss granulomatous inflammation, eosinophilia, asthma.
How to distinguish Wegener and Microscopic polyangiitis?
In Wegener upper respiratory infections: sinusitis, rhinitis. Cough, nose deformation. Affected lungs, kidney, skin. Polyangiitis. Necrozing granulomatous inflammation. c-ANCA.
What type of inflammation is in Wegener and Churg-Strauss?
Necrozing granulomatous infalmmation.
Most often caused kidney disease in SLE?
Diffusive proliferative glomerulonephritis.
What 2 diseases can present as nephritic-nephrotic?
Diffusive and membrano proliferative glomerulonephritis.
LM - wire looping of capillaries, IF - granular, EM - subendothelial depositions (sometimes intramembranous). What disease? Deposits are consisted of ……..
Diffusive proliferative glomerulnephritis. IgG based often with C3
What diesease presents with wire looping capillaries?
Diffusive proliferative glomerulonephritis.
Where are deposits in diffusive proliferative glomerulonephritis?
Subendothelial granular.