Nephrology-CV

Question 1

Acute Interstitial Nephritis

Answer 1

-abrupt onset of signs/sx ~15 days after drug use
Sx:
  -Fever, rash, joint pain
  -Eosinophilia, ^Serum IgE
  -50%: acute renal failure (BUN:CR  trigger Type 1 or IV hypersensitvity rx
Type I:
   -^IgE
Type IV:
   -mononuclear/granulomatous infiltrate

Question 2

AIN (Acute interstitial Nephritis):

Type I vs Type IV hypersensitivity

Answer 2

Type I
^IgE
Type IV:
^Mononuclear cells, granulomatous infiltrate

Question 3

Analgesic Nephropathy

Answer 3

-chr excessive intake of analgesics
–> chr tubulointerstitial nephritis
+ renal papillary necrosis
-Major cause: acetaminophen, aspirin
Other causes: caffeine, codeine, phenacetin
-Most common complication= renal papillary necrosis