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🧠📖💯 > Neoplasms - Buzz > Flashcards

Neoplasms - Buzz Flashcards

1
Q

Perivascular pseudorosettes

A

Ependymomas

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2
Q

Pseudopalisading areas of necrosis

A

Glioblastoma

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3
Q

Candle guttering

A

SEGA

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4
Q

Rosenthal fibers

A

Pilocytic astrocytomas

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5
Q

Fried egg appearance, chickenwire vasculature, secondary structures of scherer

A

Oligodendrogliomas

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6
Q

Homer Wright Rosettes

A

Medulloblastoma

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7
Q

Compact, elongated

Antoni A/B?

A

Antoni A

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8
Q

Loose, reticulated

Antoni A/B?

A

Antoni B

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9
Q

Antoni A & B

A

Schwannoma

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10
Q

Psammoma Bodies

A

Meningioma

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11
Q

MC WHO Grade I Glioma

A

Pilocytic Astrocytoma

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12
Q

MC Malignant PBT

A

Glioblastoma

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13
Q

MC tumor to hemorrhage

A

Oligodendroglioma

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14
Q

MC spinal cord glioma

A

Ependymoma

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15
Q

MC intracranial tumor in the first year of life

A

Choroid plexus tumors

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16
Q

MC malignant tumor of childhood

A

Medulloblastoma

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17
Q

MC PBT in adults

A

Meningioma

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18
Q

MC tumor of the pineal gland

A

GCTs

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19
Q

MC cause of intraaxial posterior fossa tumors in adults

A

Hemangioblastoma

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20
Q

MC sellar tumor

A

Pituitary adenoma

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21
Q

MC type of pituitary adenoma

A

Prolactinoma

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22
Q

MC supratentorial tumor in childhood

A

Craniopharyngioma

23
Q

MC intradural/intramedullary spinal tumor

A

Gliomas & ependymomas

24
Q

MC intradural/extramedullary spinal tumor

A

Schwannomas

25
Q

MC intracranial tumors in adults

A

Brain mets

26
Q

MC location of Anaplastic Astrocytoma

A

Frontal and temporal lobes

27
Q

MC location of Ependymomas

A

4th ventricle

28
Q

MC location of Myxopapillary ependymomas

A

Filum terminale

29
Q

MC location of choroid plexus tumors

A

Lateral ventricles

30
Q

MC location of Medulloblastoma

A

Inferior vermis

31
Q

MC location of spinal vertebral mets

A

Vertebral body

Thoracic

32
Q

MC locations of Ependymomas

A) In children
B) In adults

A

A) In children: Intracranial (90%) - infra>supra - 4th v

B) In adults: Spinal Cord

33
Q

MC location of choroid plexus papillomas

A) in children
B) in adults

A

A) In children: lateral ventricles

B) In adults: 4th ventricle

34
Q

GCT incidence:

a) Age
b) Sex predilection

A

10-12 yo

M>F

35
Q

MC location of meningiomas

A

90% intracranial

MC: skull base, dural folds

36
Q

Top 3 common locations of intracranial schwannomas

A

CN VIII > V > VII

37
Q

Neurofibromas are composed of

A

Schwann cells
Perineural cells
Fibroblasts

38
Q

Top 3 most common pituitary secreting adenomas

A

Prolactinoma > GH > ACTH

39
Q

Dominant type of hormone-secreting cell in the anterior lobe of the pit gland

A
  1. GH
  2. Prolactin
  3. ACTH
  4. LSH/FSH
  5. TSH
40
Q

IHCs:

a) GBM and melanomas
b) GBM
c) Melanoma

A

GBM & melanoma: S100, vimentin

Melanoma: HMB 45

GBM (+/-): GFAP, Keratin

41
Q

Tumors that can appear as cystic lesions w/ an enhancing mural nodule on MRI gado?

A

PPGH

Pilocytic astrocytoma
Pleomorphic xanthroastrocytoma
Ganglion cell tumors
Hemangioblastoma

42
Q

Tumors typically located near the foramen of Monro?

A

SSCC

SEGA
Subependymoma
Central neurocytoma
Colloid cysts

43
Q

Anaplastic astrocytoma is associated w/ molecular abnormalities involving:

A

CDKN2 suppressor

44
Q

Neuroblastoma is associated w/ molecular abnormalities involving:

A

N-myc oncogene

45
Q

WHO grade II astrocytoma is associated w/ molecular abnormalities involving:

A

p53 tumor-suppressor gene, chromosome 17p

46
Q

NF1 is associated w/ molecular abnormalities involving:

A

Neurofibromin

47
Q

Most consistent chromosomal abnormality in GBM

A

Gain of chromosome 7

Others
loss of ch 9p, 10, 17p

48
Q

Primary, de novo GBM is associated with which genes? (2)

A

PTEN

EGFR

49
Q

Which molecular features are:

a) Shared bet Well-differentiated and anaplastic ODGs?
b) Seen in anaplastic ODGs only?

A

Well-diff & anaplastic: loss of 1p, 19q

Anaplastic: loss of 9p, CDK2NA

50
Q

Most common endocrine abnormalities of:

a) GCT, suprasellar
b) Hamartoma, hypothalamic gliomas

A

GCT (suprasellar): Diabetes insipidus

Hamartoma, hypothalamic gliomas: precocious puberty

51
Q

Which CSF tumor markers are elevated in:

a) Mixed GCTs (2)
b) Choriocarcinoma (1)

A

Mixed GCTs: B HCG, AFP

Choriocarcinomas: B HCG

52
Q

MC origin or mets causing epidural spinal cord compression

A
  1. Breast
  2. Lung
  3. Prostate
  4. Lymphoma
53
Q

Predominantly affected sensory modality in paraneoplastic sensory neuronopathy

A

Proprioception

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