Neoplasms - Buzz Flashcards

1
Q

Perivascular pseudorosettes

A

Ependymomas

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2
Q

Pseudopalisading areas of necrosis

A

Glioblastoma

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3
Q

Candle guttering

A

SEGA

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4
Q

Rosenthal fibers

A

Pilocytic astrocytomas

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5
Q

Fried egg appearance, chickenwire vasculature, secondary structures of scherer

A

Oligodendrogliomas

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6
Q

Homer Wright Rosettes

A

Medulloblastoma

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7
Q

Compact, elongated

Antoni A/B?

A

Antoni A

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8
Q

Loose, reticulated

Antoni A/B?

A

Antoni B

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9
Q

Antoni A & B

A

Schwannoma

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10
Q

Psammoma Bodies

A

Meningioma

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11
Q

MC WHO Grade I Glioma

A

Pilocytic Astrocytoma

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12
Q

MC Malignant PBT

A

Glioblastoma

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13
Q

MC tumor to hemorrhage

A

Oligodendroglioma

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14
Q

MC spinal cord glioma

A

Ependymoma

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15
Q

MC intracranial tumor in the first year of life

A

Choroid plexus tumors

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16
Q

MC malignant tumor of childhood

A

Medulloblastoma

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17
Q

MC PBT in adults

A

Meningioma

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18
Q

MC tumor of the pineal gland

A

GCTs

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19
Q

MC cause of intraaxial posterior fossa tumors in adults

A

Hemangioblastoma

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20
Q

MC sellar tumor

A

Pituitary adenoma

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21
Q

MC type of pituitary adenoma

A

Prolactinoma

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22
Q

MC supratentorial tumor in childhood

A

Craniopharyngioma

23
Q

MC intradural/intramedullary spinal tumor

A

Gliomas & ependymomas

24
Q

MC intradural/extramedullary spinal tumor

A

Schwannomas

25
MC intracranial tumors in adults
Brain mets
26
MC location of Anaplastic Astrocytoma
Frontal and temporal lobes
27
MC location of Ependymomas
4th ventricle
28
MC location of Myxopapillary ependymomas
Filum terminale
29
MC location of choroid plexus tumors
Lateral ventricles
30
MC location of Medulloblastoma
Inferior vermis
31
MC location of spinal vertebral mets
Vertebral body | Thoracic
32
MC locations of Ependymomas A) In children B) In adults
A) In children: Intracranial (90%) - infra>supra - 4th v B) In adults: Spinal Cord
33
MC location of choroid plexus papillomas A) in children B) in adults
A) In children: lateral ventricles B) In adults: 4th ventricle
34
GCT incidence: a) Age b) Sex predilection
10-12 yo M>F
35
MC location of meningiomas
90% intracranial | MC: skull base, dural folds
36
Top 3 common locations of intracranial schwannomas
CN VIII > V > VII
37
Neurofibromas are composed of
Schwann cells Perineural cells Fibroblasts
38
Top 3 most common pituitary secreting adenomas
Prolactinoma > GH > ACTH
39
Dominant type of hormone-secreting cell in the anterior lobe of the pit gland
1. GH 2. Prolactin 3. ACTH 4. LSH/FSH 5. TSH
40
IHCs: a) GBM and melanomas b) GBM c) Melanoma
GBM & melanoma: S100, vimentin Melanoma: HMB 45 GBM (+/-): GFAP, Keratin
41
Tumors that can appear as cystic lesions w/ an enhancing mural nodule on MRI gado?
PPGH Pilocytic astrocytoma Pleomorphic xanthroastrocytoma Ganglion cell tumors Hemangioblastoma
42
Tumors typically located near the foramen of Monro?
SSCC SEGA Subependymoma Central neurocytoma Colloid cysts
43
Anaplastic astrocytoma is associated w/ molecular abnormalities involving:
CDKN2 suppressor
44
Neuroblastoma is associated w/ molecular abnormalities involving:
N-myc oncogene
45
WHO grade II astrocytoma is associated w/ molecular abnormalities involving:
p53 tumor-suppressor gene, chromosome 17p
46
NF1 is associated w/ molecular abnormalities involving:
Neurofibromin
47
Most consistent chromosomal abnormality in GBM
Gain of chromosome 7 Others loss of ch 9p, 10, 17p
48
Primary, de novo GBM is associated with which genes? (2)
PTEN | EGFR
49
Which molecular features are: a) Shared bet Well-differentiated and anaplastic ODGs? b) Seen in anaplastic ODGs only?
Well-diff & anaplastic: loss of 1p, 19q Anaplastic: loss of 9p, CDK2NA
50
Most common endocrine abnormalities of: a) GCT, suprasellar b) Hamartoma, hypothalamic gliomas
GCT (suprasellar): Diabetes insipidus Hamartoma, hypothalamic gliomas: precocious puberty
51
Which CSF tumor markers are elevated in: a) Mixed GCTs (2) b) Choriocarcinoma (1)
Mixed GCTs: B HCG, AFP Choriocarcinomas: B HCG
52
MC origin or mets causing epidural spinal cord compression
1. Breast 2. Lung 3. Prostate 4. Lymphoma
53
Predominantly affected sensory modality in paraneoplastic sensory neuronopathy
Proprioception