Neoplasia Flashcards
A lesion that in an irreversible uncontrolled growth is called ____________
Neoplasia
Tumor means ?
Swelling
Cancer means?
Malignant
What are the two types of neoplasms
Benign
Malignant
What cells are present in neoplasms
Parenchymal
CT and blood vessesl
Parenchymal cells can be?
Epithelial
Mesenchymal
Are endothelial cells epithelial or mesenchymal?
Mesenchymal
Mesenchymal cells are derived from the ________
Mesoderm
Cells that are round to spindle shaped with scant cytoplasm
Mesenchymal
CT, muscle, and bone marrow are epithelial or mesenchymal cells?
Mesenchymal
Are mucosa and glands epithelial or mesenchymal
Epithelial
Epithelial cells are derived from?
Endoderm
Ectoderm
Mesoderm
Cells that are squamous/cuboidal/ columnar
Epithelial cells
The suffix for a benign epithelial cell neoplasm
-oma
The suffix for a benign mesenchymal cell neoplasm
-oma
The suffix for a malignant epithelial cell neoplasm
-carcinoma
The suffix for a malignant mesenchymal cell neoplasm
-sarcoma
The MDx for a neoplasm should include?
Location(organ)
Tissue origin
Growth behavior (benign/malignant )
Name it:
Deer with a benign growth on the dermis of the skin originating from fibrous CT
Derma fibroma
Name it:
Dog with malignant growth in nasal cavity originating from fibrous CT
Nasal fibrosarcoma
Name it
Dog with a benign growth in the dermis of the skin originating from vascular endothelium
Dermal hemangioma
Name it
Dog with a malignant growth in the spleen originating fro the vascular endothelium
Splenic hemangiosarcoma
Name it
Dog with a benign growth derived form the perianal gland
Perianal adenoma
Name it
Dog with a malignant growth derived from perianal gland
Perianal adenocarcinoma
Name it
Horse with a benign growth on the mandible
Mandibular osteoma
Name it
Dog with malignant growth in the maxilla
Maxillary osteosarcoma
Name it
Dog with a benign growth in the oral mucosa originating from squamous epithelial cells
Oral/labial papilloma
Name it
Cat with malignant growth in the organ mucosa originating from squamous epithelial cells
Oral squamous cell carcinoma
Name it
Cow with malignant growth in the lymph node
Lymphoma or lymphosarcoma
Name it
Ovarian tumor derived from more than 1 cell lineage
Ovarian teratoma
The extent to which tumor cells resemble normal parenchymal cells
Differentiation
A well-differentiated tissue will resemble what?
The tissue of origin
Is earlier or later arrest associated with malignancy
Earlier
What are features of anaplasia that are observed in malignant neoplasms
Pleomorphic
Anisokaryosis (variable nucleus size)
Nuclear hyperchomasia (extra DNA)
high N:C ratio
Prominent nucleoli
Multiple nuclei
Abnormal mitotic figures
What are the characteristics used to compare benign and malignant tumors
Differentiation
Growth rate
Local invasion
Metastasis
Benign or Malignant??
Usually lack of differentiation
Structure atypical
Variable degree of anaplasia
M
Benign or Malignant ??
Slow, progressive evasion
Rare mitotic figure
Normal mitotic figure
B
Benign or Malignant??
Slow/rapid growth
Erratic growth rate
Numberous/abnormal mitotic figures
M
Benign or Malignant??
Cohesive and expansile growth
Capsule often present
B
Benign or Malignant?
Infiltrative growth
Usually no capsule
M
Benign or Malignant??
Metastatic
M
Benign or Malignant ??
Structure similar to tissue
Slow, progressive expansive
Cohesive and expansile growth
Benign
What is the most solid criteria for determining benign/malignant?
Metastasis
What is more fatal, benign or Malignant?
Trick question
Can be both
Eg benign in the brain => death
Is a cell with an abnormal mitotic figure benign or Malignant?
M
What is the mitotic index
Number of mitosis in 10 high power fields
