Nausea/Vomiting Tx

Question 1

Which 5-HT3R antagonists have the longer half life?

Answer 1

Palonosetron, Gransetron ER

Question 2

Which 5-HT3R antagonist is has the greatest risk of causing a prolonged QT interval?

Answer 2

Dolasetron

Question 3

Which NK1R antagonists are given prior to surgery?

Answer 3

Aprepitant, Fosaprepitant

Question 4

What are the H1R antagonists used for?

Answer 4

NVP, motion sickness, vertigo

Question 5

What are the 5-HT3R antagonists used for?

Answer 5

CINV, PONV, RINV, NVP

Question 6

What are the NK1R antagonists used for?

Answer 6

CINV, PONV

Question 7

What are the D2R antagonists use for?

Answer 7

Gastroparesis, dysmotility

Question 8

Which D2R antagonist also stimulates Ach release?

Answer 8

Metoclopramide

Question 9

When pts are on what other medication are D2R antagonists contraindicated?

Answer 9

Anti-HTN meds

Question 10

What are the M1R antagonists used for?

Answer 10

Motion sickness

Question 11

What are the cannabinoid agonists used for?

Answer 11

Tx-resistant CINV

Question 12

What is the difference in metabolism in the cannabinoids?

Answer 12

Dronabinol –> single metabolite

Nabilone –> many metabolites

Question 13

What is the 3-drug regimen for CINV?

Answer 13

NK1R antag, 5-HT3R antag, Dexamethasone

Question 14

What is the 2-drug regimen for CINV?

Answer 14

5-HT3R antag, Dexamethasone

Question 15

What is the 1-drug regimen for CINV?

Answer 15

Dexamethasone OR 5-HT3R antag OR D2R antag

Question 16

Which drugs are used for motion sickness?

Answer 16

Scopolamine, Dimenhydrinate, Meclizine

Question 17

Which drugs are used for vertigo?

Answer 17

Meclizine, Cyclizine

Question 18

Which drug is used for diabetic gastroparesis?

Answer 18

Metoclopramide

Question 19

Which drug is first line for NVP?

Answer 19

Doxylamine