Antacids/Anti-Ulcer Tx

Question 1

What is MOA of Simethicone?

Answer 1

Creates gas by decreasing surface tension

Question 2

Which H2R antagonist inhibits T binding to androgen receptors?

Answer 2

Cimetidine

Question 3

Which H2R antagonist is acceptable for pregnancy?

Answer 3

Ranitidine

Question 4

Which PPI is acceptable for pregnancy?

Answer 4

Lansoprazole

Question 5

What is the major SE of PPI’s that warrants immediately stopping their use?

Answer 5

CDAD

Question 6

What is the MOA of Sucralfate?

Answer 6

Creates viscous band-aid over ulcer and stimulates mucous secretion

Question 7

When is Sucralfate contraindicated?

Answer 7

Renal disease

Question 8

When are PGE1 analogs mostly used?

Answer 8

NSAID-induced gastric ulcers

Question 9

What is the MOA of Bismuth Subsalycilate?

Answer 9

Antimicrobial agent

Question 10

When is Bismuth Subsalycilate absolutely contraindicated?

Answer 10

GI bleeding, salicylate hypersensitivity

Question 11

What is the 14 day Tx regimen for H. Pylori?

Answer 11

2 ABX (clarithro, amoxi) and a PPI (or H2 antag)

Question 12

What is the 10 day Tx regimen for H. Pylori?

Answer 12

Tetra, Metro, PPI, Bismuth Subsalicylate

Question 13

If a pt has H. Pylori and a PCN allergy, which ABX do you sub in?

Answer 13

Metro

Question 14

If a pt has H. Pylori and metro resistance, which ABX do you sub in?

Answer 14

Tetra

Question 15

If a pt has H. Pylori and clarithro resistance, which ABX do you sub in?

Answer 15

Amoxi or Tetra