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Zak, GI 2 > Diarrhea/Constipation Tx > Flashcards

Diarrhea/Constipation Tx Flashcards

1
Q

What are the opioid agonists for diarrhea Tx?

A

Loperamide, Diphenoxylate, Eluxadoline

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2
Q

What is the MOA of Loperamide?

A

Decrease GI transit time

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3
Q

What is the MOA of Diphenoxylate?

A

Inhibit GI motility

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4
Q

What is mixed with Diphenoxylate to prevent addiction?

A

Atropine (C-V)

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5
Q

What is the MOA of Eluxadoline?

A

Opioid agonist in GI (C-IV)

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6
Q

What is the SE associated with Eluxadoline?

A

Pancreatitis in pts with no gallbladder

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7
Q

What is MOA of Alosetron?

A

Inhibits GI 5-HT3R

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8
Q

When is Alosetron used?

A

When severe IBS-D is unresponsive to other Tx

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9
Q

What is the major SE of Alosetron?

A

Constipation –> Ischemic colitis

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10
Q

What is the MOA of Crofelemer?

A

Inhibits Cl secretion by CFTR

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11
Q

When is Crofelemer used?

A

In non-infectious diarrhea in HIV/AIDs pts

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12
Q

What type of drugs are used for abdominal pain?

A

Antimuscarinic’s

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13
Q

When would you not give a saline agent for constipation?

A

In pts with renal disease, CHF/HTN

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14
Q

Which constipation drug family would you give to a pt with severe liver disease?

A

Osmotic agents

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15
Q

Which drug can be taken daily in small doses for constipation?

A

PEG-3350

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16
Q

What is the difference between Methylnaltrexone and Naloxegol?

A

Methylnaltrexone is IV

Naloxegol is PO

17
Q

What is the MOA of Methylnaltrexone and Naloxegol?

A

Opioid receptor antagonists (OIC)

18
Q

What is the MOA of Linaclotide?

A

Stimulates secretion of Cl/HCO3 from CFTR channel into GI lumen

19
Q

When is Linaclotide used?

A

IBS-C, CIC

20
Q

What is the MOA of Lubiprostone?

A

PGE1 derivative that increases GI Cl channel secretion

21
Q

When is Lubiprostone used?

A

IBS-C, CIC, OIC

Zak, GI 2 (16 decks)

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