Na channels, Type 1 Anti-arrhtymia

Question 1

class IA blocks what

Answer 1

fast Na channels, mainly in open or inactivated state

Question 2

Quinidine other MOA besides Na block

Answer 2

also blocks muscarinic and alpha block

Question 3

Quinidine uses

Answer 3

many arrhytmias but like it alot for A-Fib

Question 4

Quinidine SE

Answer 4

cinchonism(tinnitus, ocular dysfxn, CNS excitation, GI distress), hypotension, torsades rhytem

Question 5

hyperkalemia enhances what with quinidine?

Answer 5

V-arrythmia SE

Question 6

Procainamide class

Answer 6

Class Ia

Question 7

Procainamide metabolism by

Answer 7

N-acetyltransferase

Question 8

Procainamide SE

Answer 8

SLE like Sx(+ antihistone), hematotoxicity, CV effects including torsades rhythm

Question 9

Quinidine class

Answer 9

class Ia

Question 10

class 1B blocks what

Answer 10

blocks inactivated Na channel and also the slow Na window current causing decrease of action potential duration (makes plataue phase end faster)

Question 11

class 1B helps what kind of tissue?

Answer 11

blocking their inactivated channels of hypoxic or ischemic tissue

Question 12

Lidocaine is what class

Answer 12

class IB

Question 13

Lidocaine uses

Answer 13

Post MI, open heart surgery, digoxin toxicity

Question 14

Lidocaine SE

Answer 14

CNS toxicity, least cardiotoxic of conventional antiarrythmics, used IV

Question 15

Mexiletine and Tocainide class

Answer 15

class IB

Question 16

mexiletine and tocainide are…

Answer 16

lidocaine derivatives available orally

Question 17

class IC block what

Answer 17

block any Na channel shape

Question 18

Flecainide is what class

Answer 18

class 1C

Question 19

Flecainide SE

Answer 19

VERY high chance for fatal arrythimia