Gout Tx

Question 1

Colchicine MOA

Answer 1

binds to tubilun to lower polymerization, decrease LTB4, decrease leukocyte migration, decrease granulocyte migration

Question 2

colchicine SE

Answer 2

acute: diarrhea, GI pain
Chronic: hematuria, alopecia, gastritis, myelosuppression, peri. neuropathy

Question 3

NSAIDs used for acute gout Tx

Answer 3

Ibuprophen and Indomethacin

Question 4

corticosteroids used for acute gout

Answer 4

prednisone. methylprednisone

Question 5

Allopurinol MOA

Answer 5

metabolized by xanthine oxidase to become active and then inhibit enzyme

Question 6

Allopurinol SE

Answer 6

rash, hypoxanthine stones

Question 7

Allopurinol inhibits

Answer 7

6-MP metabolism

Question 8

Probenecid MOA

Answer 8

inhibits prox. tubule reabsorption of urate, and inhibits secretion of many acidic drugs

Question 9

Probenecid needing of what

Answer 9

good renal fxn

Question 10

probenecid SE

Answer 10

crystallization of the uric acid, ASA may decrease its effectiveness

Question 11

Losartan MOA for gout

Answer 11

AT1 antagonist with some increase of uric acid secretion

Question 12

Rasburicase and Pegloticase MOA

Answer 12

convert urate to more soluble chemical allantoin

Question 13

Febuxostat MOA

Answer 13

inhibits xanthine oxidase