N - Cells and Tissues Flashcards
Chapter 3
▪ They are the structural units of all living things
▪ The human body has 50 to 100 trillion ___
▪ Are about 60% water
Cells
The Cell Theory
- A cell is the basic structural and functional unit of living organisms
- The activity of an organism depends on the collective activities of its cells
- According to the principle of complementarity, the biochemical activities of cells are dictated by their structure (anatomy) which determines their function (physiology).
- Continuity of life has a cellular basis
Most cells are composed of four elements
▪ Carbon
▪ Hydrogen
▪ Oxygen
▪ Nitrogen
Three Main Regions or Parts of the Cell
▪ Nucleus
▪ Cytoplasm
▪ Plasma membrane
▪ Control center of the cell
▪ Contains genetic material known as
deoxyribonucleic acid, or DNA
Nucleus
DNA is needed and necessary for
▪ Building proteins
▪ Cell reproduction
Three Regions of the Nucleus
▪ Nuclear envelope (membrane)
▪ Nucleolus
▪ Chromatin
▪ Consists of a double membrane that bounds the nucleus
▪ Contains nuclear pores that allow for an exchange of material with the rest of the cell
Nuclear envelope
Encloses the jellylike fluid called the
Nucleoplasm
▪ Nucleus contains one or more dark staining nucleoli
▪ Sites of ribosome assembly
▪ Ribosomes migrate into the cytoplasm through nuclear pores to serve as the site of protein synthesis
Nucleolus
▪ Composed of DNA wound around histones (proteins)
▪ Scattered throughout the nucleus and present when the cell is not dividing
▪ Condenses to form dense, rodlike bodies called chromosomes when the cell divides
Chromatin
▪ Transparent barrier for cell contents
▪ Contains cell contents
▪ Separates cell contents from the surrounding environment
Plasma Membrane
Model that is constructed of two layers of phospholipids arranged “tail-to-tail”, cholesterol and proteins scattered among phospholipids, and sugar groups
Fluid Mosaic Model
Sugar groups may be attached to the phospholipids, forming
Glycolipids
What makes the phospholipids a good foundation for cell membrane?
Property of polarity
▪ “water loving”
▪ polar “heads” are oriented
on the inner and outer surfaces of the membrane
Hydrophilic
▪ “water fearing”
▪ nonpolar “tails” form the
center (interior) of the membrane
Hydrophobic
Protein is responsible for specialized membrane functions
▪ Enzymes
▪ Receptors for hormones or other chemical messengers
▪ Transport as channels or carriers
Branched sugars attached to proteins that abut the extracellular space
Glycoproteins
The fuzzy, sticky, sugar-rich area on the cell’s surface
Glycocalyx
Cells are bound together in three ways:
- Glycoproteins in the glycocalyx act as an adhesive or cellular glue
- Wavy contours of the membranes of adjacent cells fit together in a tongue and groove fashion
- Special cell membrane junctions are formed, which vary structurally depending on their roles.
Cell Junctions
▪ Impermeable junctions
▪ Bind cells together into leakproof sheets
▪ Plasma membranes fuse like a zipper to prevent
substances from passing through extracellular space
between cells
Tight Junctions
Cell Junctions
▪ Anchoring junctions, like rivets, that prevent cells from being pulled apart as a result of mechanical stress
▪ Created by buttonlike thickenings of adjacent plasma
membranes
Desmosomes
Cell Junctions
▪ Allow communication between cells
▪ Hollow cylinders of proteins ( connexons ) span the width of the abutting membranes
▪ Molecules can travel directly from one cell to the next through these channels
Gap Junctions OR Communicating Junctions
▪ The cellular material outside the nucleus and
inside the plasma membrane
▪ Site of most cellular activities
▪ Includes cytosol, inclusions, and organelles
Cytoplasm
Fluid that suspends other elements and contains nutrients and electrolytes
Cytosol
Chemical substances, such as stored nutrients or cell products, that float in the cytosol
Inclusions
Metabolic machinery of the cell that performs functions for the cell
Organelles
▪ “Powerhouses” of the cell
▪ Mitochondrial wall consists of a double membrane with
cristae on the inner membrane
▪ Carry out reactions in which oxygen is used to break down food into ATP molecules
Mitochondria
▪ Made of protein and ribosomal RNA ▪ Sites of protein synthesis in the cell ▪ Found at two locations: = Free in the cytoplasm = As part of the rough endoplasmic reticulum
Ribosomes
▪ Fluid filled tunnels (or canals) that carry substances within the cell
▪ Continuous with the nuclear membrane
Endoplasmic Reticulum (ER)
ER
▪ Studded with ribosomes
▪ Synthesizes proteins
▪ Transport vesicles move proteins within the cell
▪ Abundant in cells that make and export proteins
Rough Endoplasmic Reticulum
ER
▪ Lacks ribosomes
▪ Functions in lipid metabolism
▪ Detoxification of drugs and pesticides
Smooth Endoplasmic Reticulum
▪ Appears as a stack of flattened membranes associated with tiny vesicles
▪ Modifies and packages proteins arriving from the rough ER via transport vesicles
▪ Produces different types of packages
Golgi Apparatus
Pathways of Golgi Apparatus
▪ Secretory vesicles (pathway 1)
▪ In house proteins and lipids (pathway 2)
▪ Lysosomes (pathway 3)
▪ Membranous “bags” that contain digestive enzymes
▪ Enzymes can digest worn out or nonusable cell structures
▪ House phagocytes that dispose of bacteria and cell debris
Lysosomes
▪ Membranous sacs of oxidase enzymes
▪ Detoxify harmful substances such as alcohol and formaldehyde
▪ Break down free radicals (highly reactive chemicals)
▪ Free radicals are converted to hydrogen peroxide and then to water
▪ Replicate by pinching in half or budding from the ER
Peroxisomes
▪ Network of protein structures that extend throughout the cytoplasm
▪ Provides the cell with an internal framework that determines cell shape, supports organelles, and provides the machinery for intracellular transport
Cytoskeleton
Three different types of elements form the
cytoskeleton
▪ Microfilaments (largest)
▪ Intermediate filaments
▪ Microtubules (smallest)
▪ Rod-shaped bodies made of nine triplets of
microtubules
▪ Generate microtubules
▪ Direct the formation of the mitotic spindle during cell
division
Centrioles
Cell Extensions
▪ It moves materials across the cell surface
▪ Located in the respiratory system to move mucus
Cilia
Cell Extensions
▪ Propel the cell
▪ Sperm
Flagella
Cell Extensions
▪ Are tiny, fingerlike extensions of the plasma
membrane
▪ Increase surface area for absorption
Microvilli
Secretes cable like fibers
Fibroblast
Carries oxygen into the bloodstream
Erythrocyte (Red Blood Cell)
▪ Cells that cover and line body organs
▪ Packs together in sheets
▪ Intermediate fibers resist tearing during rubbing or
pulling
Epithelial Cell
▪ Cells that move organs and body parts
▪ Contractile filaments allow cells to shorten forcefully
▪ Skeletal Muscle Cells
▪ Smooth Muscle Cells
▪ Cell that stores nutrients
▪ Lipid droplets stored in the cytoplasm
Fat Cells
▪ Cell that fights disease
▪ Digests infectious microorganisms
White Blood Cells
Macrophage (phagocytic cell)
▪ Cell that gathers information and controls body functions
▪ Receives and transmits messages to other body
structures
Nerve Cell (neuron)
▪ Cells of reproduction
▪ Largest cell in the body
▪ Divides to become an embryo upon fertilization
Oocyte (female)
▪ Cells of reproduction
▪ Built for swimming to the egg for fertilization
▪ Flagellum acts as a motile whip
Sperm (male)
Cells have the ability to
Metabolize Digest food Dispose of wastes Reproduce Grow Move Respond to a stimulus
Homogeneous mixture of two or more components
Solution
▪ Dissolving medium present in the larger quantity
▪ The body’s main solvent is water
Solvent
Components in smaller quantities within a
solution
Solutes
▪ Nucleoplasm and cytosol
▪ Solution containing gases, nutrients, and salts dissolved in water
Intracellular Fluid
▪ Fluid on the exterior of the cell
▪ Contains thousands of ingredients, such as nutrients, hormones, neurotransmitters, salts, waste products
Extracellular Fluid (interstitial fluid)
Methods of Transport
Substances are transported across the membrane without any input from the cell
Passive Processes
Passive Process
▪ Molecule movement is from high concentration to low concentration, down a concentration gradient
▪ Particles tend to distribute themselves evenly within a
solution
▪ Size of the molecule and temperature affect its speed
Diffusion
▪ Energy of motion
▪ Energy that causes the molecules to move about randomly
Kinetic Energy
Molecules will move by diffusion if the molecules are (3)
▪ small enough to pass through the membrane’s pores (channels formed by membrane proteins) ▪ lipid-soluble ▪ assisted by a membrane carrier
Types of Diffusion
▪ An unassisted process
▪ Solutes are lipid-soluble or small enough to pass
through membrane pores
Simple Diffusion
Types of Diffusion
▪ Simple diffusion of water across a selectively permeable membrane
▪ Highly polar water molecules easily cross the plasma membrane through aquaporins
▪ Water moves down its concentration gradient
Osmosis
Solutions have the same solute and water concentrations as cells and cause no visible changes
in the cell
Isotonic solutions
Solutions contain more solutes than the cells do; the cells will begin to shrink
Hypertonic solutions
Solutions contain fewer solutes (more water) than the cells do; cells will plump
Hypotonic solutions
Types of Diffusion
▪ Transports lipid insoluble and large substances
▪ Glucose
▪ Protein membrane channels or protein molecules that act as carriers are used
Facilitated Diffusion