n-Acetylcysteine (mucomyst, Acetadote) Flashcards

1
Q

Class

A

Antidote, mucolytic

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2
Q

Mechanism of action

A

Primary and most effective treatment for acetaminophen overdose. Also administered as a mucolytic to patients with thick pulmonary secretions from a variety of lung conditions.

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3
Q

Onset and duration

A

Peak:
PO: 1-2 hours
Duration: 5.6 hour half life

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4
Q

Indications

A

Acetaminophen overdose

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5
Q

Contraindications

A

Hypersensitivity, acute asthma

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6
Q

Adverse reactions

A
Nausea/ vomiting 
Edema
Flushing 
Tachycardia 
Hypotension
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7
Q

Drug interactions

A

None

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8
Q

How supplied

A

10% and 20% oral solutions, 20% IV solution (30 ML)

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9
Q

Dosage and administration - adult and pediatric

A

Oral: 140 mg/kg loading dose, followed by 70 mg/kg q 4 hours for 17 additional doses
IV: 300 mg/kg in 3 doses over 21 hours: loading dose of 150 mg/ kg in 200 ml of 5% dextrose over 1 hour, second dose 50mg/kg in 500 ml over 4 hours, 3rd dose 100 mg/kg in 1000 ml over 16 hours
Contact poison control for dosing in pediatrics < 20kg

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10
Q

Special considerations

A

Pregnancy safety category B
Consult medical control prior to administration
Consider activated charcoal instead if within 1 hour of ingestion
Nausea and vomiting frequently occur with Oral administration, consider antiemetic

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