Acetazolamide(Diamox sequels) Flashcards

1
Q

Class

A

Carbonic anhydrase inhibitor; Anticonvulsant, diuretic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Mechanism of Action

A

Used for acute mountain sickness, also used for edema, chronic heart failure, glaucoma, and certain seizure disorders. Causes increased excretion of bicarbonate, sodium and potassium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Onset and Duration

A

Onset:
Tablets:1-2 hours. IV: 2-10 minutes
Duration:
Tablets: 24 hours IV: 4-5 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Indications

A

Acute mountain sickness, altitude sickness prophylaxis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Contraindications

A

Hypersensitivity to acetazolamide or sulfa drugs, hyponatremia, hypokalemia, known metabolic acidosis, liver or renal disease, noncongestive angle-closure glaucoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Adverse reactions

A
Tinnitus
Nausea/vomiting 
Diarrhea 
Metabolic acidosis 
Various electrolyte imbalances
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Drug interactions

A

May cause insoluble precipitate in urine when administered with methenamine, may increase toxicity from cisapride

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How supplied

A

125 mg and 500 mg tablets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Dosage and administration- Adult and pediatric

A

2.5 mg/kg per dose up to 250 mg PO Q 12 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Special considerations

A

Pregnancy safety category C

Not recommended in acute mountain sickness prophylaxis In pediatrics except in certain high risk situations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly