Aspirin

Question 1

Class

Answer 1

Analgesic, anti-inflammatory, antipyretic, antiplatelet

Question 2

Mechanism of action

Answer 2

Decreases inflammation, dilates peripheral vessels, decreased platelet aggregation

Question 3

Onset and duration

Answer 3

Onset: 15-30 minutes
Duration: 4-6 hours; anti platelet effects may persist 4-10 days

Question 4

Indications

Answer 4

Mild to moderate pain or fever; prevention of platelet aggregation in ischemia and thromboembolism; All patients with acute coronary syndrome; symptoms of ischemic chest pain; unstable angina; prevention of MI or infarction

Question 5

Contraindications

Answer 5

Hypersensitivity to salicylates; GI bleed; active ulcer disease or acute asthma; hemorrhagic stroke; bleeding disorders; children with flu-like symptoms

Question 6

Adverse reactions

Answer 6

Stomach irritation; heartburn or indigestion; nausea or vomiting; allergic reaction

Question 7

Drug interactions

Answer 7

Decreased effects with antacids or steroids; increased effects with anticoagulants, insulin, oral hypoglycemics, fibrinolytic agents

Question 8

How supplied

Answer 8

81mg tablets

Question 9

Dosage and administration

Answer 9

Adult: Mild pain and fever: 325-650mg PO q 4 hours. ACS: 160-325mg PO chewable tablets
Pediatric: not indicated in prehospital setting

Question 10

Special considerations

Answer 10

Give ASAP to patients with ACS; Not routinely used as analgesic In Prehospital setting