Myocardial Infarction Flashcards

1
Q

What can be defined as the rapid development of myocardial necrosis by a critical imbalance between oxygen supply and demand to the myocardium?

A

Myocardial Infarction

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2
Q

What are the 3 acute coronary syndromes?

A
  • ST-elevation MI (STEMI)
  • Non ST-elevation MI (NSTEMI)
  • Unstable angina
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3
Q

Which type of MI has a better and which has a worse prognosis?

A

NSTEMI has a better prognosis than STEMI

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4
Q

How many coronary arteries are there?

A

2

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5
Q

-% of patients have abnormal coronary arteries (1 or 3)

A

7-8

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6
Q

If the myocardium receives at least __% of oxygen the heart will function

A

60%

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7
Q

A quadruple bypass involves what arteries?

A
  • Right marginal artery
  • Posterior descending artery
  • Circumflex artery
  • Left Anterior Descending artery (LAD)
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8
Q

What are the 5 layers of the heart from outer to innermost?

A
  • Fibrous pericardium
  • Parietal pericardium
  • Visceral pericardium
  • Myocardium
  • Endocardium
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9
Q

Which layer of the heart is the thickest?

A

myocardium

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10
Q

What percentage of arterial blood goes to the myocardium?

A

95%

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11
Q

What do transmural and non-transmural means?

A
  • Transmural = Full thickness

- Non-transmural = Partial thickness

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12
Q

What are ECGs good at depicting?

A

Q wave changes

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13
Q

What are 5 signs and symptoms indicative of MI?

A
  • Anterior “precordium” tightness
  • Pain that radiates to the jaw, neck, left elbow or pinky, and epigastrium
  • Dyspnea
  • Nausea/abdominal pain
  • Anxiety
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14
Q

Describe how increased blood flow through congested arteries can get progressively worse over time

A

Increased blood flow may cause a “ripping” of the plaques on the artery walls which exposes the underlying collagen. The body will then send platelets to the area which only makes the area more congested.

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15
Q

What is the most frequent cause of MI?

A

rupture of an atherosclerotic lesion within coronary wall with subsequent spasm and thrombus formation

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16
Q

What are the most important indicators of MI?

A

Cardiac Biomarkers

17
Q

What are Cardiac Biomarkers?

A

protein molecules released into the blood stream from damaged heart muscle

18
Q

What are the 5 cardiac biomarkers?

A
  • Troponin T and I
  • Creatinine Kinase (CK-MB)
  • Myoglobin
  • C-reactive Protein (CRP)
19
Q

What are the preferred markers for detect myocardial cell injury?

A

Troponin T and I

20
Q

Troponin T and I begins to rise - hours after injury
Peaks __-__ hours after
Stays elevated for _-__ days

A

2-6

12-16

5-14

21
Q

Creatine kinase begins to rise - hours after injury
Peaks __ hours after
Stays elevated for _ days

A

4-6

24

2

22
Q

Myoglobin begins to rise _ hours after injury
Peaks - hours after
Stays elevated for __-__ hours

A

2

6-8

20-36

23
Q

What is C-reactive Protein (CRP) a marker of?

A

acute inflammation

24
Q

Patients without evidence of myocardial necrosis but with elevated CRP are at increased risk for what?

A

a MI

25
Q

What are the goals of therapy in acute MI?

A

expedient restoration of normal coronary flow and maximal salvage of functional myocardium