Chronic Inflammation Flashcards
Chronic inflammation is ___-limited and ____ in duration
self
short
What 2 things may chronic inflammation be the result of?
- a recurrent or progressive acute inflammatory process
- from low-grade, smoldering responses that fail to evoke an acute response
What is characteristic of chronic inflammation?
An infiltration by mononuclear cells (macrophages) and lymphocytes instead of the influx of neutrophils seen in acute
Chronic inflammation involves the proliferation of ____ instead of exudates.
fibroblasts
Because fibroblasts infiltrate during chronic inflammation what is an involved risk?
scarring and deformity
What are the 2 patterns of chronic inflammation?
- nonspecific chronic inflammation
- granulomatous inflammation
What does nonspecific chronic inflammation involve?
a diffuse accumulation of macrophages and lymphocytes at the site of injury
Ongoing ______ causes macrophages to infiltrate the inflamed site, where they accumulate owing to prolonged survival and immobilization
chemotaxis
What does this accumulation of macrophages to?
fibroblast proliferation, with subsequent scar formation
What is a granuloma?
a small, 1-2 mm lesion in which there is a massing of macrophages surrounded by lymphocytes
What do granulomas oftentimes called and why?
Epithelioid cells, because they resemble epithelial cells
What is granulomatous inflammation associated with?
- splinters
- sutures
- silica
- sarcoidsis
- deep fungal infections
- brucellosis
Epithelioid cells often clump in a mass in an attempt to surround the foreign agent. A dense membrane of connetive tissue eventually encapsulates the lesion and is often referred to as what?
foreign body giant cells
