Myeloproliferative neoplasms

Question 1

What is myeloproliferative neoplasm

Answer 1

Clonal myeloid conditions where blood production is unregulated and independent of growth factors. High RBCs.

Question 2

What are the qualities of polycythemia vera

Answer 2

Acquired MPN. Overproduction of RBCs. Age is 60 and survival is 15 years

Question 3

What can polycythemia vera turn into

Answer 3

Risk of transformation to Myelofibrosis or AML.

Question 4

Primary vs secondary polycythemia

Answer 4

Primary- Increased RBCs because of a mutation in RBC progenitor cells
Secondary- Something else causes EPO increase which causes increased RBCs

Question 5

Secondary conditions that cause polycythemia

Answer 5

Inherited
Hypoxia, Pulmonary, high altitude, tumors, smoking leads to increased EPO leads to more RBCs

Question 6

Clinical manifestations of Polycythemia

Answer 6

Puritis, erythromegalgia ( burning pain in feet or hands), headache, fatigue, plethora

Question 7

Erythrocytosis definition

Answer 7

Increased elevation of Hemoglobin and hematocrit in peripheral blood

Question 8

IF you see facial plethora polycythemia vera what disease are you considering

Answer 8

Polycythemia vera ( polycythemia, type of myeloproliferative neoplasm)

Question 9

What is a band

Answer 9

Immature neutrophil (often bc of acute infection)

Question 10

What are the lab value changes for Tumor lysis syndrome

Answer 10

Uric acid, potassium, phospherus all hyper, Calcium goes down (HypOcalcemia)