Lecturio quiz questions Flashcards
Which type of cell is the characteristic histologic feature of Hodgkin’s lymphoma?
Reed-Sternberg cells
What is the function of The regulatory protein BCL2?
Inhibit Apoptosis
What is the most common type of non-Hodgkin lymphoma?
Diffuse large B-cell lymphoma
What histological feature is seen in Burkitt lymphoma?
Starry sky
To which of the following body parts is lymphoblastic lymphoma more likely to metastasize?
Testicles
Which of the following cells are most often associated with chronic lymphocytic leukemia?
Smudge Cells
which white blood cells respond in the acute phase of inflammation?
Neutrophils
Basophils
Lymphocytes
Monocytes
neutrophils
How might the nurse be able to tell the difference between a viral infection and a bacterial infection through the results of a complete blood count (CBC)?
Neutrophils are elevated in bacterial infections, and lymphocytes are elevated in viral infections.
What is likely to occur in a client’s WBCs if the client is infected with human immunodeficiency virus (HIV)?
Lymphocytopenia
What is expected to occur to the hematocrit level collected from a dehydrated client?
Hematocrit levels will rise
How much is each unit of packed red blood cells (PRBCs) expected to raise the hematocrit level?
~3%
Which component of a complete blood count (CBC) is used to help diagnose the type, cause, and severity of an anemia?
MCHC
What can cause a decrease to both the mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH)?
Anemia of chronic disease
Which component of the red blood cell count is most affected by the client’s hydration status?
Hematocrit
An important mediator of primary hemostasis is…
…von Willebrand factor.
What is the end product of the coagulation cascade?
Fibrin
What factor activates the extrinsic pathway?
Tissue factor
What principally drives the coagulation cascade after an injury?
Extrinsic pathway
Thrombin cleaves which of the following factors?
V, VIII, XIII
5, 8, 13
Thrombin is necessary for which of the following events?
Endothelial activation
What factor do the endothelial cells synthesize?
VIII (8)
What is the function of the heparin-like molecule?
Inhibits Thrombin
Thrombomodulin acts as a…
Coagulation inhibitor
What substances play an essential role in the extrinsic pathway?
Ca ions and factor 7a
Antithrombin III activity is enhanced by…
Heparin
What cleaves the fibrin clot?
Plasmin
Thrombolysis results in the formation of…
…fibrin degradation products.
Fibrin degradation products are important prognostic indicators of what condition?
Pulmonary Embolism
Coagulation factors assemble on the phospholipid surface of what substance?
Platelets
What test helps to diagnose a disease that causes uncontrollable clotting?
D-dimer
Platelet dysfunction and decreased platelet aggregation may be caused by which of the following?
NSAIDs
PTT is particularly useful to measure which of the following?
Intrensic pathway
PTT has to be monitored in patients who are on which drug?
Heparin
Which of the following is found in higher amounts in beta-thalassemia major?
Hb F
Which of the following conditions will result in a mild increase in HbA2, mild decrease in HbA1, a normal fetal hemoglobin, and absent Hb H on electrophoresis ?
Beta-thalassemia trait
What is the common complication of treatment of thalassemia?
Iron Overload
Which of the following does NOT cause a decrease in red blood cell production?
Aplastic anemia
Polycythemia Vera
Carcinoma infiltration
Myeloproliferative disease
Leukemia
Polycythemia Vera
Which red cell mass and plasma volume would you expect in a patient with primary polycythemia?
Increased Red cell mass and normal plasma volume
Which gene is commonly associated with polycythemia vera?
JAK 2
What cell types are predominantly involved in acute leukemia?
Early hemopoietic progenitor cells
Which of the following cells is is seen in myeloid leukemia on a bone marrow aspirate?
Primitive myeloblasts
what is the most common presentation of chronic lymphoid leukemia?
Elevated lymphocites noted on labs ordered for other reasons
Which B-cell receptor signalling pathway is blocked in order to inhibit the proliferation signals produced by tumor cells?
BTK (Burton’s kinases)
Which of the following is a characteristic feature of the blood smear in chronic lymphocytic leukemia?
Smudge Cells
The characteristic feature is the presence of what kind of cells in Hodgkin lymphoma
Reed Sternberg cells
Which of the following viruses is implicated in a subset of cases of Hodgkin lymphoma?
EBV
Which of the following is required to make a definitive diagnosis of Hodgkin lymphoma?
Biopsy of affected tissue
