Hypercoagulable disorders

Question 1

What is the most common inherited hypercoagulable state

Answer 1

Factor V leiden (Procoagulent, helps us clot, in the common pathway)

Question 2

Why is factor V level not helpful in diagnosing Factor V leiden

Answer 2

The problem in factor V leiden is not the level of it, but that protein C cannot bind to factor V, so the anti-clotting loop is interrupted.

Question 3

What are two distinct proteins that are made by the liver for anticoagulation (and have associated hyper coagulable diseases)

Answer 3

Protein C and protein S

Question 4

Which hypercoagulable disorder can you test the levels of the factor?

Answer 4

Antithrombin 3– you can test the levels

Question 5

Where is DVT most common in pregnant women

Answer 5

in the LEFT lower extremity, compress left iliac vein

Question 6

DVT is accompanied by which increased levels?

Answer 6

Increased levels of fibrinogen, factor 8, and vWF.
Increases pro-coagulent factors

Question 7

When is the highest risk for blood clots in women

Answer 7

Postpartum, has a risk that is 2-5x that of during pregnancy. Very high risk after birth

Question 8

How long after giving platelets do you see a patient’s platelet count rise

Answer 8

2-3 days
Platelets live for 8-10 days, and platelets will only raise in recipient for a few days after whole process