Myeloproliferative diseases Flashcards
1
Q
4 causes of increased EPO due to tissue hypoxia
A
High altitude
Lung disease
Cyanotic heart disease
High affinity haemoglobins
2
Q
Causes of inappropriately increased EPO x5
A
Renal disease
Hepatoma
Phaeochromocytoma
Bronchogenic carcinoma
Cerebellar haemangioblastoma
3
Q
Malignant thrombocytosis causes x4
A
CML
Myelofibrosis
Polycythemia rubra vera
Essential thrombocythemia
4
Q
Reactive thrombocytosis causes x6
A
Tissue damage
Malignant disease
Hemolytic anemia
Post splenectomy
Post hemorrhage
Chronic inflammatory disorders
5
Q
3 characteristics of myelofibrosis
A
Bone marrow fibrosis
Extramedullary hematopoiesis > massive spleen
Leukoerythroblastic blood picture
6
Q
Treatment of myelofibrosis x5
A
Folic acid
Hydroxyurea
Splenectomy
Bone marrow transplant
Transfuse RBCs and platelets
7
Q
A
