Myeloproliferative Flashcards
1
Q
Define myeloproliferative?
A
- bone marrow lineage of granulocytes, red cells and platelets
- proliferation of mature cells
2
Q
How can myeloproliferative neoplasms be categorised?
A
- BRC-ABL1 negative
- BRC-ABL1 postitive
3
Q
Name the BCR-ABL1 negative disorders?
A
- primary myelofibrosis
- polycythaemia vera
- essential thrombocytopenia?
4
Q
What are the BCR-ABL1 positive conditions?
A
- Chronic myeloid leukaemia
- due to the Philadelphia chromosome
5
Q
What are the typical features of MPN?
A
- High granulocytes
- high red cells
- high platelets
- eosinophilia
- splenomegaly
6
Q
Define CML
A
- Proliferation of myeloid cells
- BCR-ABL1 positive
7
Q
What are the phases of CML?
A
- Chronic
- Accelerated
- Blast crisis
8
Q
What are some of the typical features of CML?
A
- Splenomegaly
- gout
9
Q
What would the bone marrow appear like in CML?
A
- Hypercellular
10
Q
Lab features of CML?
A
- Anaemia
- leucocytosis with neutrophilia
- philadelphia chromosome
11
Q
What is the Philadelphia chromosome?
A
- seen in CML
- 9:22
- product is an abnormal tyrosine kinase porduct
12
Q
Treatment of CML?
A
- Tyrosine kinase inhibitor
- imatinib
13
Q
What is polycythaemia vera?
A
- high haemoglobin
- erythrocytosis?
14
Q
what may be causes of secondary polycythaemia?
A
- chronic hypoxia
15
Q
What may be the causes of pseudopolycythaemia?
A
- dehydration
- diuretics
- obesity
