Mycobacterium - Exam 2 Flashcards
What is the best way to stain Mycobacterium and why?
Acid-fast stain
LIPID RICH CELL MEMBRANE!
Long and complex micolic acids present in cell membrane
True/False. Mycobacterium in anaerobic.
FALSE!
AEROBIC!
What are the important diseases caused by Mycobacterium spp.?
Tuberculosis
Paratuberculosis (Johne’s Disease)
Granulomatous disease
What is the most important virulence factor that Dr. Soto does not want us to forget about Mycobacterium?
LIPID RICH CELL WALL!!
True/False. Tuberculosis is not a reportable disease.
FALSE! REPORT IT!
How is Mycobacterium transmitted?
Via the respiratory and alimentary routes
MILK FROM INFECTED MAMMARY GLANDS IS A SUPER IMPORTANT WAY PEOPLE GET THIS!
Which species of Mycobacterium affects the respiratory tract, adjacent lymph nodes, and serous cavities?
Mycobacterium bovis
What species of Mycobacterium mainly infects swine and how?
M. Bovis via the alimentary route
Which species of Mycobacterium mainly infects cats and dogs?
M. Bovis
Primates are susceptible to which species of Mycobacterium?
M. bovis (via ingestion [unpastuerized milk])
M. tuberculosis (aiborne route)
Birds are naturally susceptible primarily to which species of Mycobacterium?
M. avium
True/False. There is no zoonosis with tuberculosis.
False! REVERSE ZOONOSES!
True/False. Tuberculosis is typically a disease of captivity and domestication.
True
Which of the following is NOT a characteristic of tubercle bacilli:
- very hardy
- resistant to many antimicrobial and disinfectants
- survive short periods in soil and resist drying
-survive short periods in soil and resist drying
THIS IS NOT A CHARACTERISTIC OF TUBERCLE BACILLI
they survive for LONG periods in soil and resist drying
Which species of Mycobacterium causes Johne’s disease in cattle?
M. avium subsp. paratuberculosis
True/False. Johne’s disease is a reportable disease.
True! REPORT IT!
What is the main reservoir for M. avium subsp. paratuberculosis?
Sympomatic and asymptomatic wild and domestic ruminants, swine and rabbits
What is the main mode of transmission for M. avium subsp. paratuberculosis?
Fecal-oral
(in utero infection and ingestion of contaminated colostrum or milk are also possible routes)
Which animals are the most susceptible to M. avium subsp. paratuberculosis? Young or old animals?
Young animals
What type of stain is used for acid-fast stain?
Ziehl-Neelsen
True/False. M. avium subsp. paratuberculosis has a laboratory growth dependency for mycobactin.
True
The failure to eliminate the bacteria from host is due to the activation of what being compromised?
IFN-gamma
Which cattle breeds are predisposed to Johne’s disease?
Guernsey and Jersey
Which species of Mycobacterium causes feline leprosy?
M. lepraemurium
(chronic noduloulcerative-nontuberculous mycobacterial infection of the skin)
