[Myaesthenia Gravis] Flashcards
1
Q
A
Myaesthenic snarl
(preserved vertical but decreased horizontal excursion of lips)
2
Q
A
voice fades on counting to 50
3
Q
A
Tendon reflexes normal
4
Q
A
Females
Thymic hyperplasia
5
Q
A
Males
thymic atrophy/tumours
6
Q
A
nicotinic acetylcholine receptors
7
Q
A
ocular muscle fatigue
difficulty swallowing/speaking
8
Q
A
Shows orbicularis fatigue
9
Q
A
Anti-AchR
10
Q
A
70
11
Q
A
MuSK (muscle specific tyrosine kinase)
12
Q
A
Decremental muscle response
13
Q
A
> 2mm
14
Q
A
CT of thymus
15
Q
A
Pyridostigmine (anticholinesterase)
16
Q
A
Prednisolone
+ azathioprine/d
OR
Methotrexate /week
17
Q
A
alternate days
18
Q
A
Osteoporotic prophylaxis
19
Q
A
methotrexate
20
Q
A
azothioprine
21
Q
A
Thymectomy
22
Q
A
respiratory muscle fatigue during relapse
23
Q
A
Forced vital capacity
24
Q
A
FBC
LFT
25
[MG]: involvement of muscel groups starts at ... and ends with .. muscle involvement
ocular
(bulbar, face, neck, limb)
Truck
26
[MG]: pyridostigmine SEs i.e. cholinergic (3)
salivation
lacrimation
miosis
27
[MG]: 5 days pre-op to thymectomy what may be give
IV Immunoglobulin
28
[MG]: Myasthenic crisis is the major medical concern. What is it.
life threatening weakness of respiratory muscles in relapse
29
[MG]: What is the FVC for ventilatory support
<20mL/Kg
30
[MG]: Tx for myasthenic crisis (2)
plasmapheresis
or
IV Ig
31
[lambert-eaton}: what is the difference in presentation between MG and LE myasthenic syndrome?
gait difficulty before eye signs
32
[lambert-eaton}: what is the pathophysiological cause of LES?
Antibodys against pre-synaptic membrane Calcium voltage channels
33
[lambert-eaton}:LES can be autoimmune or caused by ...
small cell lung cancer (paraneoplastic)
