[dementia]

Answer 1

AMTS (abbreviated mental test score)
TYM (test your memory)

Answer 2

Alzheimers
Vascular dementia
Lewy body dementia
Fronto-temporal dementia (aka Pick’s)

Answer 3

vascular

Answer 4

Fluctuating cognitive impairment
Visual hallucinations
Parkinsonism

Answer 5

brainstem
neocortex (outermost layer of hemispheres)

Answer 6

Frontal
temporal

Answer 7

Ch.9

Answer 8

Episodic (autobiographical)

Answer 9

Picks

Answer 10

Trazodone(night)
Lorazepam

Answer 11

Lewy body

Answer 12

Downs syndrome

Answer 13

enduring global cognitive impairment (cf. certain domains affected only)

Answer 14

Visuo-spatial skill
executive function
anosognosia (lack of insight into problems caused by AD)
Memory
verbal ability

Answer 15

Accumulation of b-amyloid peptide

Answer 16

Acetylcholine neurotransmitter loss
amyloid plaques deposition
Neurofibrillary tangles

Answer 17

Hippocampus
amygdala
temporal neocortex
subcortical nuclei

Answer 18

loneliness (not just living alone)

Answer 19

vascular

Answer 20

B-amyloid changes in CSF

Answer 21

15

Answer 22

rivastigmine (Ach i)

Answer 23

they can exacerbate pre-existing heart block

Answer 24

Donepezil
Rivastigmine
Galantamine

Question 25

[dementiaMx]: What drug may be effective in late stage disease

Answer 25

Memantine (NMDA antagonist)

Question 26

[dementiaMx]: In early AD which drug targets b-amyloid

Answer 26

Solanezumab

Question 27

[dementiaMx]: Which 2 supplements decrease mild impairment if homocysteine is >11micromol

Answer 27

B12 Folic acid

Question 28

[dementia]: sudden onset dementia with step-wise deterioration indicates what cause

Answer 28

vascular (multiple small strokes)

Question 29

[dementia]: dementia onset over weeks indicates depression might be a cause T/F

Answer 29

T

Question 30

[dementia]: why might excess alcohol cause dementia

Answer 30

reduced thiamine

Question 31

[dementia]: can reduced T4, folate or B12 cause dementia

Answer 31

yes

Question 32

[alzheimers]: homozygosisty for the ... allele is a risk factor

Answer 32

Apolipoprotein E e4

Question 33

[alzheimers]: what 3 gene mutations are associated with AD

Answer 33

CL1 CLU PICALM

Question 34

[alzheimers]: acetylcholinesterase inhibitors may worsen what 2 conditions

Answer 34

heart block peptic ulcer

Question 35

[alzheimers]: why is BP control so important

Answer 35

huge interplay between vasculopathy and AD

Question 36

[alzheimers]: what are the 2 broad mainstay Txs

Answer 36

BP control Acetylcholinesterase inhibitors