MUSCULOSKELETAL 7- tumours Flashcards
85% of bone tumours are what kind of tumour?
Osteosarcoma
Osteosarcomas are typically located where is alrge rbeeds
metaphysis of long bones: near knee, away from elbow
Where are osteosarcomes more common: fornt ro hind limbs:
front
2:1 front to hind
Osteosarcomas are typically located where is small rbeeds
axial skeleton.these rarely metasasise
Between osteosarcoma and chondrosarcoma, whic has a higher metastasis risk?
osteosarcoma
What is the ideal treatment option for osteosarcomas?
What are some other options?
amputation
others: limb sparing, chemo, radiation
What si the best chemotherapy drug for osteosarcomas?
carboplatin
Which appendicular bone ahs the worst prognosis in osteosarcomas?
humerus
feline osteosarcomas: how often appendicular vs axial?
hindlimb vs forelimb?
comparative metastatic potential?
55% appendicular, 45% axial
more hindlimb
lower metastasis
sarcomas arise form which 2 types of tissue in the body?
mesenchymal, soft tissue
how is the metastasis risk for sarcomas?
are they locally invasise?
variable
yes
What is the differnce in stagina dn grading a tumour
staging: location(s)
grading: histological
What type of biopsy is used to diagnose a sarcoma?
incisional
CT and MRI are better than radiographs to diagnose musculoskeletal tumours. why?
bone lysing is not visible on radiographs until 60% gone
all soft tissues look the same
Side note on lymph node metastasis in musculoskeletal tumours
these guys metastasis haematogenously: more likely to affec tliver, spleen
what tissue do soft tissue sarcomas originate from?
mesenchymal
ST sarcomas: large or small dogs?
where do they typically arise?
large
anywhere
two types of soft tissue srcomas discussed?
haemangiosarcoma
histioytic sarcoma
haemangiosarcomas most commonly affect which organ
spleen
how si the metastasis for histiocytic sarcoma?
high
What are two cancer drugs discussed?
these are metabolised mainly in which organ?
severe ________irritant
doxyrubicin& epirubicin
liver
severe perivascular irritant
