Muscles, joints, tendons and ligaments Flashcards
Filaments in each myofibril are arranged into what? Thick filaments made of? Contains what act as molecular spring too? Dark bands called what?Proteins that link central region of A band?
Sarcomeres Myosin Titin A bands M line
Length and diameter of thick filament? How many per filament? How many heavy and light chains? Thin filament made of? Light band just actin called what?
1.6 micrometers long and 15nm diameter
300
2 heavy and 4 light chains
I band
I bands anchored to what? Length and diameter of thin filament? How many per filament? Filaments (F-actin) made of monomers of what? F-actin makes a chain of 2 what?
Z line 1 micrometer long and 8nm diameter 380 per filament Globular protein G-actin 2 alpha helices
What is tropomyosin and what does it do? 3 troponin types? What does each do?
Double alpha helix around actin- partially covers myosin binding sites on actin filament
Tn I- inhibitory
Tn T- binds tropomyosin
Tn C- binds calcium
Membrane AP propagates through what? Ca2+ in sarcoplasm combines with what causing what? Energised by what? What breaks link between actin and myosin? When does contraction end?
T- tubules
Troponin- allows tropomyosin to move away from myosin binding site on actin
ATP hydrolysis
Binding of new ATP molecule
When Ca2+ returns to ECF by Ca2+/ATPase pumps and Na+/Ca2+ counter transporters
What is needed for energy for muscle contraction? When is creatinine kinase released?
High energy from ATP and creatinine phosphate- short term energy store, replenished by creatinine kinase- released on muscle fibre damage
Functions of joints? 3 structural joint types? Examples of each?
Allows movement, weight bearing and transfers load evenly to MSK system
Fibrous, cartilaginous and synovial
Fibrous= teeth sockets, cartilaginous= intervertebral discs, synovial= metacarpophalangeal
3 functional joint types and examples?
Syntharthroses- immovable joints e.g. skull sutures
Ampiathroses- slightly moveable e.g. intervertebral discs
Diarthroses- freely moveable joints e.g. hip
What are sutures?
Between bones of skull- allow growth in development, adjacent ones interdigitate and filled with short connective tissue
What are syndesmoses?
Bones connected by a ligament/ sheet of fibrous tissue e.g. interosseous membrane between trivia fibula
What are gomphoses?
Peg in socket fibrous joint found inly in tooth articulation
What are 3 fibrous joint types? 2 types of cartilaginous types?
Sutures, syndesmoses, gomphoses
Synchondroses and symphyses
What are synchondroses?
Bones directly connected by hyaline cartilage e.g. costal cartilage of ribs
What are symphyses?
Connecting cartilage is a pad/ plate of fibrocartilage e.g. intervertebral discs
What are synovial joints known as? The 5 components of synovial joints?
Freely moveable joints
1) Articular cartilage 2) Joint capsule 3) Joint (synovial) cavity 4) Synovial fluid 5) Reinforcing ligaments
Features of articular cartilage?
Almost frictionless surface, resists compressive loads, high water content, low cell content, no blood supply
What is the inner layer of the joint capsule? What is the external layer? Features of the synovial membrane?
The synovial membrane
It’s continuous with periosteum (tough, fibrous)
Only few cells thick, can have villi and projections to increase SA, secretes synovial fluid components
What is the synovial cavity filled with? What does the synovial fluid cover, what is it modified from and what is in it?
Synovial fluid
Covers articulating surfaces with thin film- reducing friction during articulation
By plasma from synovial membrane
Fluid, proteins, charged sugars that bind water e.g. hyaluronate
3 types of reinforcing ligaments in synovial joints? What do ligaments do?
Intrinsic- thickened part of fibrous capsule
Extrinsic- outside capsule
Intracapsular- deep to capsule covered with synovial membrane
They connect bone to bone, stabilise joints and have less regularly arranged fibres than a tendon
What do tendons do and what do they have?
Connect bone to muscle, stabilise joints, allow muscles to be accommodated at a distance from their insertion, provides solid base on which muscles can pull
Dense, regular connective tissue
3 types of cartilage? Composition? What are proteoglycans made of and what do they do?
Elastic, fibrocartilage, hyaline cartilage
Water, proteoglycan, collagen and ions
PPC to which are covalently attached chains of sulphated disaccharide repeating units
High density of -ve charges allows binding of water, conferring properties of compressive stiffness and friction-free surfaces e.g. aggrecan
3 synovial joint lever types? Where is fulcrum, weight and resistance in 1st class levers?
1st, 2nd and 3rd class levers. Fulcrum in middle, force is at one end and resistance is at other e.g. elbow joint and triceps muscle
Fulcrum, weight and resistance in 2nd class lever?
Fulcrum at one end, force at other end and resistance in centre e.g. mandible joint
Fulcrum, resistance and force in 3rd class lever?
Fulcrum at one end, resistance at other end and force in middle e.g. below joint and biceps muscle
Movements of synovial joints and examples?
Ball and socket e.g. hip, shoulder
Condyloid e.g. metacarpal
Gliding joint e.g. intercarpals, femur/patella, humerus/ radius
Hinge joint e.g. humerus/ ulna
Pivot joint e.g. Atlanta-axis joint
Saddle joint e.g. between trapezius and 1st metacarpals
What is the major component of the tendon and ligament fibres? What makes up 1-5% of the dry weight? What does this act to do?
Collagen- mainly type 1 (90-95% dry weight)
Proteoglycan
Regulates fibre diameter, keeps fibrils together, acts as a lubricant to aid collagen fibres gliding over each other
Where are collagen molecules synthesised and as what? Consists of what? 3 alpha chains combine in a what? What between alpha chains enhances strength of molecules?What occurs after secreting outside the cell?
In fibroblasts as procollagen
3 individual PPCs each coiled in left hand helix
A right handed triple helix
Bonding(cross-linking)
Processed to remove terminal peptides- for tropocollagen and self assembles into collagen fibrils
Hierarchal structure of collagen–> tendons? (fibrillogenesis) What are fascicles separated by? What is the tendon surrounded by?
Collagen molecules–> microfibrils–> sub fibrils–> fibrils–> fibres–> fascicles–> tendon
Endotenon
Epitenon
What other molecule do tendons and ligaments contain? How does collagen I content, elastin content and fibre organisation differ between ligaments and tendons?
Elastin- more elasticity, proportion varies by function
Ligaments= lower collagen I, higher elastin, fibre organisation more random
What are the major ligaments of the knee? Function of each?
ACL- provides rotational stability and resists anterior translation of the tibia.
PCL- resists posterior translation of the femur.
MCL- resists valgus force on the knee
LCL- resists varus force
6 degrees of freedom of the knee?
Internal/ external rotation
Varus/ valgus
Flexion/ extension
What is locking of the knee? What isn’t true locking?
An inability to fully straighten the knee due to a mechanical block, usually a piece of cartilage/ loose body.
If cannot flex/extend/ if fully flexed or fully extended.
Are MCL and LCL injuries common or rare? Are PCL or ACL injuries more common?
MCL= common, LCL= rare
PCL less common than ACL
What is valgus knee also known as? What is varous knee also known as?
‘Knee-knock’
‘Bowed knee’
What is not part of the wrist joint? Articulates as what instead? Prevented from articulating with carpal bones by what?
Ulna
Distal radioulnar joint
Articular disk
Four ligaments of the wrist?
Palmar radiocarpal
Dorsal radiocarpal
Ulnar collateral
Radial collateral
What type of joint is the wrist joint? What movements can it perform? Why is the scaphoid at wrist of avascular necrosis?
Ellipsoidal
Flexion, extension, adduction, abduction
Its retrograde blood supply entering at its distal end- fracture to the middle may interrupt blood supply to the proximal part
Most common fracture of the wrist? This clinical condition produces what?
Colles’ fracture- radius fractures with the distal fragment being displaced posteriorly
‘Dinner fork deformity’
How can the lunate be dislocated anteriorly? Causing what symptoms? What can also happen?
By falling on a dorsiflexed wrist
Carpal tunnel symptoms
Avascular necrosis
Types of distal radius fracture? What is less common than distal radius fractures and how does it present?
Colles’= extra-articular with dorsal displacement
Smith’s= extra-articular with volar displacement
Barton’s= intra-articular with dislocation of the radiocarpal joint
Fracture of the radial shaft- ROM= typically pain-free
What forms the glenohumeral joint? Humerus articulates with what distally?
Proximal humerus–> glenoid fossa of the scapula
Head of the radius and trochlear notch of the ulna
Attachment site for supraspinatus, infraspinatus and teres minor? Attachment for subscapularis? Separating the 2x tuberosities? What attaches to the lips of this?
Greater tuberosity
Lesser tuberosity
Inter-tubercular sulcus= pec major, teres major and latissimus dorsi
Neurovascular structures lying against surgical neck of humerus? Axillary nerve damage would paralyse which muscles? Difficulty doing what movement? Also innervates what area?
Axillary nerve and posterior circumflex artery–> deltoid and teres minor paralysis
Abduction of the affected limb
Regimental badge area
Lateral side on humeral shaft where deltoid attaches? Shallow depression on posterior surface? What lies in this groove?
Deltoid tuberosity
Radial groove= radial nerve and profunda brachii artery
Muscles attaching anteriorly to the humeral shaft? Posteriorly?
Coracobrachialis, deltoid, brachialis, brachioradialis
Medial + lateral heads of triceps