muscles Flashcards

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1
Q

what is the connective tissue layer surrounding the muscle?

A

epimysium

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2
Q

describe a muscle

A

fascicles (bundles of muscle fibres) surrounded by the epimysium

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3
Q

what is the connective tissue layer that surrounds each fascicle?

A

the perimysium

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4
Q

what does calcium bind to during muscle contraction?

what does this result in?

A

binds to troponin

rolls tropomysin away from binding sites of actin filaments

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5
Q

skeletal muscle histology

A

very long
multinucleated
striated
cylindrical

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6
Q

what is the connection between the nervous system and the skeletal muscle fibre?

what neurotransmitter is released here?

A

neuromuscular junction

ACh

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7
Q

what gives skeletal muscle its striated appearance?

A

alternating bands of actin and myosin

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8
Q

what are the steps in initiating muscle contraction?

A
  1. ACh released, binds to receptors
  2. action potential reaches T-tubule
  3. sarcoplasmic reticulum releases calcium
  4. active site exposure, cross bridge formation
  5. contraction begins
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9
Q

describe the regeneration ability of muscle

A

poor regenerative ability

damage leads to fibrosis (scar tissue)

no regeneration in cardiac muscle

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10
Q

how do cardiac muscles store oxygen?

A

in myoglobin

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11
Q

smooth muscle features

A

uni-nucleated

spindle shaped

non-striated

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12
Q

which type of muscle cells are branched?

A

cardiac muscle

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13
Q

which type of muscle cells are not striated?

A

smooth muscle

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14
Q

ER-like organelle in muscle cells?

A

sarcoplasmic reticulum

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15
Q

what are the three types of muscle cells?

A

cardiac muscle
smooth muscle
skeletal muscle

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16
Q

what is the functional unit of contraction called?

A

the sarcomere

17
Q

what is atrophy?

A

decrease in size/shrinkage of muscle size due to lack of use

18
Q

give an example of an isometric contraction

A

carrying a bag of groceries

holding head up

19
Q

what is the connective tissue layer that surrounds each muscle fibre?

A

the endomysium

20
Q

what are the roles of muscles in the body?

A
  1. movement
  2. support soft tissues
  3. maintain posture and body position
  4. thermoregulation
  5. storage of nutrients
  6. guards body entrances and exits
21
Q

during exercise, haemoglobin releases more oxygen to active skeletal muscles than when those muscles are at rest. why?

A

more heat generated
more acidic wastes generated.

both make haemoglobin release more oxygen

22
Q

what is a muscle cell also known as?

A

a muscle fibre

23
Q

what is the point of attachment that doesn’t change when muscle contracts

A

the origin

24
Q

name the three types of myofilaments

A

actin
myosin
titin

25
Q

cytoplasm of a muscle

A

sarcoplasm

26
Q

point of attachment of a muscle: the end that is freely moveable

A

insertion

27
Q

define circumduction

A

movement of arm in a circular motion

movement of hand in a circular motion without moving arm

28
Q

what is muscle tone? what does it do?

A

degree of contraction or undertone in resting muscles

posture
joint stabililty
ready response state

29
Q

what are the movements in the anterior-posterior plane?

A

flexion (smaller angle - hand towards inner arm)

extension - hand in a line with arm

hyperextension - wrist bending back towards forearm

30
Q

what is agonist /antagonist with reference to muscles?

A

the contracted muscle is the agonist

the relaxed muscle is the antagonist

31
Q

what’s the cell membrane of a muscle called?

A

the sarcolemma

32
Q

the russian doll of muscle organisation

A

muscles each contain:

many fascicles which each contain:

many muscle fibres which each contain:

many myofibrils which each contain:

many myofilaments.

33
Q

what is the thin myofilament called? the thick? the elastic?

A

actin (thin)

myosin (thick)

titin (elastic)

34
Q

define hyperplasia

A

increase in cell number

occurs in skeletal muscle subjected to persistent increased workload (eg. weights, bodybuilding)

35
Q

how are myosin heads activated in the muscle contraction process?

A

ATP binds to myosin head and breaks into ADP and P

myosin head is now cocked and can bind with actin when troponin binds wuth calcium

when it binds, it pulls the actin along

36
Q

what is ATPs role in muscle contraction?

A

attaches to myosin head and releases it from the actin

ATP then breaks into ADP and P and the head is activated again

37
Q

steps in initiating muscle relaxation?

A
  1. ACh broken down by AChE at neuromuscular junction
  2. sarcoplasmic reticulum recaptures calcium
  3. active sites covered, no cross bridge formation
  4. contraction ends
  5. relaxation occurs, passive return to resting length
38
Q

what happens to actin and myosin, and to the sarcomere, during muscle contraction?

A

actin and myosin overlap, which shortens the sarcomere, causing contraction