heart anatomy and physiology Flashcards

1
Q

where is the sinoatrial node located?

A

in the posterior wall of the right atrium

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2
Q

what does the moderator band do?

A

conducts the impulse from the bundle branches to the anterior papillary muscle of the right ventricle

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3
Q

what does the QRS complex on an ECG represent?

A

ventricular depolarisation

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4
Q

trace the path of an action potential through the conducting system

A

sinoatrial node → internodal pathways → atrioventricular node → AV bundle → bundle branches → purkinje fibres

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5
Q

where is the heart positioned in the body?

A

posterior to the sternum, in the mediastinum between the two pleural cavities, in the pericardial sac

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6
Q

what is the role of connective tissue fibres in the epicardium?

A

physical support
distributes contractile forces
prevents overexpansion
elasticity - helps heart return to its original size and shape

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7
Q

how long does the cardiac cycle last?

A

about 0.8 seconds

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8
Q

what are three ways to diagnose MI?

A

ECG

troponin levels (Tn I) - more troponin, more damage

creatine kinase (non specific)

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9
Q

what are the symptoms of MI?

A
severe, prolonged, crushing pain
dyspnoea
cool, clammy skin
sweating
pallor
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10
Q

what is the difference between STEMI and non STEMI MIs?

A

STEMI - complete blockage of coronary artery

non STEMI - partial obstruction - tissue damage not as bad

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11
Q

what is the formula for measuring BMI?

A

weight divided by (height squared)

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12
Q

where is the atrioventricular node located?

A

in the floor of the right atrium, near the septum

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13
Q

what is the left AV valve also know as?

A

bicuspid valve or mitral valve

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14
Q

what is isovolumetric contraction?

A

all valves are closed, ventricles contracting (same volume).

like squeezing a bottle with the lid on - pressure increases, but volume remains the same

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15
Q

what are the two types of cardiac muscle cell and what do they do?

A

conducting system cells: control and coordinate the heartbeat

contractile cells: produce contraction that propel blood

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16
Q

what do width and height equal on an ECG?

A

height equals voltage

width equals time

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17
Q

what effect would an increase in venous return have on stroke volume?

A

increased venous return = more stretch in heart muscle = greater force of contraction = higher stroke volume

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18
Q

what effect would an increase in sympathetic stimulation of the heart have on end-systolic volume?

A

increased heart rate and increased force of contraction leads to higher stroke volume = lower end-systolic volume

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19
Q

define end-diastolic volume (EDV) and end-systolic volume (ESV)

A

EDV - amount of blood in left in the ventricle at the end of relaxation

ESV - amount of blood left in the ventricle at the end of contraction

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20
Q

list the phases of the cardiac cycle

A

atrial systole
atrial diastole
ventricular systole
ventricular diastole

21
Q

what is stroke volume?

what is it measured in

A

the amount of blood that leaves the heart with each beat

ml/beat

22
Q

which blood vessels supply the heart with oxygenated blood?

A

coronary arteries

23
Q

describe the pericardium

A

pericardial sac - visceral and parietal layers with pericardial cavity containing pericardial fluid in between

serous membrane!

24
Q

what are the characteristics of cardiac muscle cells?

A

small
branched
single nucleus
intercalated discs

25
what are the three layers of the heart wall, from inner to outer?
endocardium myocardium epicardium
26
describe the tissue layers of the epicardium
serous membrane exposed mesothelium and underlying layer of areolar tissue areolar layer is attached to the myocardium
27
what is hypertrophy
increase in size of cell ie cardiac muscle hypertrophy due to increased workload
28
what is contractility? | what is necessary for increased contractility?
the strength of contraction more calcium from sympathetic innervation and/or hormonal stimulation from adrenaline/noradrenaline
29
how much of the cardiac cycle is spent in diastole compared to systole?
two thirds diastole | one third systole
30
what effect would hypertension have on afterload, and what would this mean for the ventricles?
afterload would be increased ventricle would have to pump harder to open SL valve, would probably pump out less blood per stroke increased arterial pressure = increased ventricular contraction = ventricle more tired = increased ESV, decreased SV
31
how is stroke volume measured?
SV = EDV - ESV
32
what is ejection fraction?
the percentage of EDV that is ejected with each contraction | so 100% = very efficient
33
at what part of the conducting system does a slight delay occur? what happens during this delay, and how long is it?
AV node 100 msec delay allows atrial contraction to occur
34
which layer of the pericardium forms part of the heart wall?
the visceral pericardium is also the epicardium
35
what are the resting potentials of atrial and ventricular cardiac cells?
ventricular - about -90 mV atrial - about -80 mV
36
what are the three layers of the heart wall called? what sort of tissue is each made of?
epicardium - epithelium and connective tissue myocardium - muscle endocardium - simple squamous epithelium
37
what is afterload?
the arterial pressure in the aorta that the ventricle must overcome to force open the SL valve
38
what accounts for internal regulation of HR?
the cardiac conduction system
39
what is the function of intercalated discs?
in cardiac muscles, gap junctions at the intercalated discs allow the cardiac muscle tissue to behave like a single enormous muscle cell
40
what is the "lubb" sound of the heartbeat in the stethescope?
AV valves closing
41
what is the "dupp" sound of the heartbeat in the stethescope?
SL valves closing
42
what stops the heart's valves from prolapsing?
chordae tendinae attached to papillary muscles
43
what happens to BP as HR and SV increase?
BP increases
44
what is preload?
what occurs before the ventricle contracts (stretch in muscle fibres) the more a muscle is stretched, the more strongly it will contract
45
what is cardiac reserve, and how much is it?
difference between resting output and maximum possible 4-5 times on average 7-8 times in top endurance athletes in disease there is little or no reserve
46
what is the main function of the heart?
to circulate blood through the body
47
what factors influence heart rate?
SNS stimulation increases HR PNS stimulation decreases HR hormones increase HR
48
what factors influence SV?
SNS increases force of contraction preload afterload