muscle disorders Flashcards
major signs of muscle disorders
muscle stiffness - tying up
weakness, staggering, muscle atrophy, muscle fasiculations
describe rhabdomyolysis
rapid degeneration of muscle cells due to excessive calcium accumulation in muscle cells.
produces free radicals, proteases, and cytokines.
what is the difference between myogenic atrophy and neurogenic atrophy
myogenic- type two. m cell destruction
neurogenic- type 1and 2. denervation. very rapid
what is a common clinical sign with HYPP
muscle fasiculation
what is hypp
-hyperkalemic periodic paralysis– from ion channel defects
what is the biggest differential for muscle disease
exercise associated or not
weakness vs pain
if there is muscle pain associated with poor performance what are we thinking
tying up. need to check CK
what causes muscle weakness poor performance
neurogenic or myogenic atrophy
what are the three exercise related diseases and how do they present differently
sporadic rhabdo-occurs randomly, inc CK
chronic rhabdo- repeat incidences, inc CK
chronic myopathy- NORMAL CK, repeat stiffness
nonexertional myopathies
metabolic, inflammatory, toxic, trauma, infection, nutritional, muscle atrophy, fasciculations
what are the key things we look at in our PE for muscular disease
muscle mass, symmetry, behavior, palpation for pain, tone, swelling
what does CK and AST tell us about whats going on
CK short acting. will tell us if the injury is acute or ongoing
AST will tell us the chronicity longterm. takes weeks to return to normal
when does CK return to normal
48 hours
what number CK are we worried about muscle damage
> 4000
how do we confirm rhabdomyolysis
CK ex response. preex
moderate exercise (not severe)
and looking for a 3x increase
