Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

EQ BCM > DJD > Flashcards

DJD Flashcards

1
Q

what two things cause morphological breakdown of the articular cartilage

A

abnormal stress on normal cartilage,
normal stress on abnormal cartilage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what are the bad guys in DJD inflammation

A

IL-1 and TNF alpha degrade cartilage/matrix

this causes more of them to release from the cells, viscous cycle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

why are the cytokines produced in the joint

A

trauma and inflammation to the synoviocytes cause cytokine release and these attach the articular cartilage chondrocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

who are the good guys during DJD

A

TIMP - active collagenase and growth factors- acting on the chondrocytes
serine proteinase inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what are the bodies natural responses to OA

A

limit ROM to limit the pain
articular cartilage breaks down and stops producing collagen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

why do we care about articular cartilage degration

A

reduced compressive and tensile strength

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

how does IRAP work

A

competes with IL-1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

how does the bone respond to all of this

A

bone sclerosis and thickening where there is increased load/stress– this decreases the ability to absorb shock

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

three big takeaways about DJD

A

multifactoral
permanent
intervene early

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what are the goals of treatment for DJD

A

decrease inflammation, lubricate joint, halt disease, alleviate pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what are the two essential clinical features of OA requiring attention

A

pain and loss of function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

conservative approach to managing OA

A

exercise modification, weight reduction, antiinflammatories, SC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what is the best mode of treatment for OA

A

joint injections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is adequan

A

PSGAG, stimulates production of HA, increase PG and collagen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what is the coctail for intraarticular medications

A

steroids, HA, regenerative medicine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

big disadvantage with intraarticular steroids

A

laminitis, risk of infection and steroids dull the reaction

17
Q

steroid of choice? and one we never use?

A

triamcinolone

depo-medrol (methylpred)

18
Q

we suspect a post injection flare- heat, pain, swelling. what is our other ddx, and what do we do

A

infection, refer to surgeon to tap

if not willing to refer, try treatment and abx

19
Q

how long do we worry about a post joint injection infection

A

as long as 2 weeks, steroids will dull the response and WBC are not as high as you would expect

20
Q

HA is most effective in treating what

A

acute synovitits

21
Q

what is polyglycan approved for

A

replacement of joint fluid following scope

22
Q

what to remember about giving PSGAGs

A

do not give with steroids

23
Q

what is the disadvantage of PRP

A

they have increased leukocytes which can cause more inflammation

24
Q

how does IRAP work

A

competes with IL-1 for receptors– receptor antagonist

25
Q

BM or Ad cells

A

no improvements seen

26
Q

what joint is diagnostic arthroscopy almost always warranted

A

stifle

27
Q

what is the primary goal of arthroscopic techniques for OA repair

A

enhancement of the repair

remove loose cartilage and bone,
remove calcified cartilage
microfracture

28
Q

what is the requirement for extrinsic repair

A

removal of the calcified cartilage so new cartilage can form in the defect space

29
Q

what techniques do we use for extrinsic repair

A

microfracture through subchondral bone to increase blood flow to the area and get better quality healing

30
Q

what joints can be fused adn still maintain function as an athlete

A

distal tarsal -DIT, TMT, Pastern PIP,
Coffin- not commonly done

31
Q

what joints can we fuse as a salvage procedure to be pasture, breeding horse

A

fetlock- MCP/MTP
carpal- partial or pan

32
Q

how does laser arthrodesis work

A

heat kills the chondrocytes and damages the nerves

33
Q

for a pastern (PIP) arthrodiesis, which has a better prognosis

A

hind better than front.

34
Q

why is fetlock arthrodiesis tough

A

the plate is on the dorsal aspect and the biomechanics work against the plate

35
Q

what are the classic radiographic signs of DJD

A

decreased joint space, osteophytes, lysis and sclerosis, enthesopathy

36
Q

horse is lame, you radiograph the hock and find fusion in the joint space, what do you do

A

since it is fused would this cause lamenes/pain? unlikely. do your blocks and look for another cause

EQ BCM (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions