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MB2 Rheumatology and Orthopaedics > Muscle disease and vasculitis > Flashcards

Muscle disease and vasculitis Flashcards

1
Q

what muscle disease is characterised by weakness

A

inflammatory myopathies - polymyositis and dermatomyositis

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2
Q

what muscle disease is characterised by pain and stiffness

A

polymyalgia rheumatics

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3
Q

what muscle disease is characterised by pain and fatigue

A

fibromyalgia

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4
Q

polymyositis and dermatomyositis affect proximal/distal muscles on the extremities

A

proximal

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5
Q

who is more likely to get polymyositis and dermatomyositis

A

women and middle age

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6
Q

dermatomyositis/polymyositis has an increased risk of malignancy

A

both do, dermatomyositis is more elevated risk

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7
Q

what cancers are common in dermamyositis/polymyositis

A 
ovarian
breast
stomach
colon 
lung 
bladder`
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8
Q

in who is cancer most likely in dermamyositis/polymyositis

A

men over 45

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9
Q

what is gottron’s sign

A

reddish, purputic rash on MCP/DIP, dorsal hand

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10
Q

what is a heliotrope rash

A

reddish, purputic rash around eyes

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11
Q

what is a shawl sign

A

reddish, purputic rash on chest on upper back

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12
Q

what is confrontational testing

A

testing that applies force to muscle group to test strength

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13
Q

what is isotonic testing

A

testing for muscle fatigue, 30s how fast can you stand/sit

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14
Q

what antibodies are present in polymyositis

A

ANA

anti-Jo-1

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15
Q

what may electromyography see on dermatomyositis/polymyositis

A

increased fibrillation

abnormal motor potentials

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16
Q

what would a muscle biopsy see in dermatomyositis/polymyositis

A

perivascular inflammation and muscle necrosis

17
Q

what would a muscle MRI see in dermatomyositis/polymyositis

A

muscle inflammation, oedema, fibrosis, calcification

18
Q

what is polymyalgia rheumatica associated with

A

temportal/giant cell arteritis

19
Q

polymyalgia rheumatica affects proximal/distal muscles

A

proximal

20
Q

fibromyalgia affects proximal/distal muscles

A

proximal

21
Q

who is fibromyalgia more common in

A

women, age 20-50

more common with emotional/physical trauma

22
Q

tender points of fibralgia

A 
upper back/shoulder 
base of neck
elbow 
knee
hip 
chest
23
Q

true/false - analgesics work effectively in fibromyalgia

A

false - they can in high doses but avoid opiods at all costs. SSRI or tricyclic antidepressants may work to relieve pain

24
Q

what is vasculitis

A

inflammation of the blood vessels

25
Q

what is primary vasculitis

A

inflammatory response targeting vessel walls

26
Q

what is secondary vasculitis

A

vasculitis triggered by infection, drug, toxin or inflammatory disorder/malignancy

27
Q

takayasu vasculitis is large/small vessel and who does it affect

A

large

<40 and females

28
Q

who does giant cell arthritis affect, where is it more common and what is a complication

A

over 50, polymyalgia rheumatica
temporal arteries
vision loss, temporary or permanent

29
Q

treatment duration for giant cell arteritis?

A

18-24 months

30
Q

EGPA is more commonly known as?

A

churg-strauss syndrome

31
Q

GPA is characterised by and is more common in who

A

granulomatous inflammation

30-50 and men

32
Q

what does EGPA have in addition to the presentation to GPA

A

high serum eosinophils

late presentation of asthma

33
Q

complication of microscopic polyangiitis

A

renal failure

34
Q

what immunoglobulin mediates henoch-schonlein purpura and where/who is it more commno in

A

IgA
skin, GI tract, kidneys, joints, lungs and CNS
children, preceding URTI, GI infection,pharyngeal infection

35
Q

what is cANCA associated with

A

GPA

36
Q

what is pANCA associated with

A

EGPA and MPA

37
Q

what is more sensitive than cANCA

A

PR3

38
Q

what is more sensitive than pANCA

A

MPO

39
Q

true/false - c/pANCA is used to monitor disease progression

A

true

MB2 Rheumatology and Orthopaedics (22 decks)

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