Immunology

Question 1

describe immunology of myasthenia gravis

Answer 1

CD4 cells and AChR antigens activate autoreactive B cells which produce autoreactive IgG antibodies against post synaptic unfolded thymic AChR
antibodies block ACh binding to AChR leading to internalisation of receptor and destroyed muscle endplate

Question 2

describe immunology of RA

Answer 2

CD4 cells recognise unknown peptide antigen
activates further TH1 and TH17 cells and macrophages
chronic inflammation of synovium, destruction of cartilage and bone