Muscle Flashcards
Troponin subunits
Troponin T
Troponin I
Troponin C
Troponin-T
binds to tropomyosin
Troponin-I
binds to actin and inhibits contraction
Troponin-C
binds to calcium
Key receptors in the flux of Ca2+ channels in the sarcoplasmic reticulim
Dihydropyridine (DHP)
Ryanodine (RyR)
DHP
Voltage-gated Ca2+ channel located in the sarcolemmal membrane
DHP functions as a voltage-sensor, when the skeletal muscle is at rest, DHP blocks RyR
RyR
is a calcium channel on the SR membrane
SERCA
sarcoplasmic endoplasmic reticulum calcium ATPase
Receptor to which acetylcholine binds
Nicotinic receptor
Ways to increase muscle contraction
Summation & recruitment
Function of titin
Allows elasticity in the muscle
Mecanisms of cytosolic Ca2+ removal in myocytes
SERCA
Na+/Ca2+ exchanger